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Management of febrile urinary tract infection among spinal cord injured patients
BACKGROUND: Urinary tract infection (UTI) among patients with neurogenic bladder is a major problem but its management is not well known. We studied the relationship between antibiotic regimen use and the cure rate of those infections among 112 patients with neurogenic bladder. METHODS: We studied a...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833936/ https://www.ncbi.nlm.nih.gov/pubmed/27084753 http://dx.doi.org/10.1186/s12879-016-1484-4 |
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author | Dinh, Aurélien Toumi, Adnène Blanc, Constance Descatha, Alexis Bouchand, Frédérique Salomon, Jérôme Hanslik, Thomas Bernuz, Benjamin Denys, Pierre Bernard, Louis |
author_facet | Dinh, Aurélien Toumi, Adnène Blanc, Constance Descatha, Alexis Bouchand, Frédérique Salomon, Jérôme Hanslik, Thomas Bernuz, Benjamin Denys, Pierre Bernard, Louis |
author_sort | Dinh, Aurélien |
collection | PubMed |
description | BACKGROUND: Urinary tract infection (UTI) among patients with neurogenic bladder is a major problem but its management is not well known. We studied the relationship between antibiotic regimen use and the cure rate of those infections among 112 patients with neurogenic bladder. METHODS: We studied a retrospective cohort of febrile UTI among patients with neurogenic bladder. Drug selection was left to the discretion of the treating physicians, in accordance with current guidelines. Patients were divided into 3 groups according to antibiotic treatment duration (<10 days, between 10 and 15 days, and >15 days). We analysed clinical and microbiogical cure rate one month after the end of antibiotic treatment. RESULTS: The three groups of patients were similar, especially in terms of drug treatment (equal distribution). The cure rates were not significantly different (71.4 %, 54.2 %, and 57.1 %, respectively; p = 0.34). Moreover, there was no difference in cure rate between mono and dual therapy (44 % for monotherapy vs. 40 % for dual therapy; p = 0.71). CONCLUSION: This descriptive study supports the efficacy of antimicrobial treatment duration of less than 10 days and the use of monotherapy to treat febrile UTI among patients with neurogenic bladder. A randomized control trial is required to confirm these data. |
format | Online Article Text |
id | pubmed-4833936 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-48339362016-04-17 Management of febrile urinary tract infection among spinal cord injured patients Dinh, Aurélien Toumi, Adnène Blanc, Constance Descatha, Alexis Bouchand, Frédérique Salomon, Jérôme Hanslik, Thomas Bernuz, Benjamin Denys, Pierre Bernard, Louis BMC Infect Dis Research Article BACKGROUND: Urinary tract infection (UTI) among patients with neurogenic bladder is a major problem but its management is not well known. We studied the relationship between antibiotic regimen use and the cure rate of those infections among 112 patients with neurogenic bladder. METHODS: We studied a retrospective cohort of febrile UTI among patients with neurogenic bladder. Drug selection was left to the discretion of the treating physicians, in accordance with current guidelines. Patients were divided into 3 groups according to antibiotic treatment duration (<10 days, between 10 and 15 days, and >15 days). We analysed clinical and microbiogical cure rate one month after the end of antibiotic treatment. RESULTS: The three groups of patients were similar, especially in terms of drug treatment (equal distribution). The cure rates were not significantly different (71.4 %, 54.2 %, and 57.1 %, respectively; p = 0.34). Moreover, there was no difference in cure rate between mono and dual therapy (44 % for monotherapy vs. 40 % for dual therapy; p = 0.71). CONCLUSION: This descriptive study supports the efficacy of antimicrobial treatment duration of less than 10 days and the use of monotherapy to treat febrile UTI among patients with neurogenic bladder. A randomized control trial is required to confirm these data. BioMed Central 2016-04-16 /pmc/articles/PMC4833936/ /pubmed/27084753 http://dx.doi.org/10.1186/s12879-016-1484-4 Text en © Dinh et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Dinh, Aurélien Toumi, Adnène Blanc, Constance Descatha, Alexis Bouchand, Frédérique Salomon, Jérôme Hanslik, Thomas Bernuz, Benjamin Denys, Pierre Bernard, Louis Management of febrile urinary tract infection among spinal cord injured patients |
title | Management of febrile urinary tract infection among spinal cord injured patients |
title_full | Management of febrile urinary tract infection among spinal cord injured patients |
title_fullStr | Management of febrile urinary tract infection among spinal cord injured patients |
title_full_unstemmed | Management of febrile urinary tract infection among spinal cord injured patients |
title_short | Management of febrile urinary tract infection among spinal cord injured patients |
title_sort | management of febrile urinary tract infection among spinal cord injured patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833936/ https://www.ncbi.nlm.nih.gov/pubmed/27084753 http://dx.doi.org/10.1186/s12879-016-1484-4 |
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