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HDAC inhibitors cause site-specific chromatin remodeling at PU.1-bound enhancers in K562 cells
BACKGROUND: Small molecule inhibitors of histone deacetylases (HDACi) hold promise as anticancer agents for particular malignancies. However, clinical use is often confounded by toxicity, perhaps due to indiscriminate hyperacetylation of cellular proteins. Therefore, elucidating the mechanisms by wh...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833939/ https://www.ncbi.nlm.nih.gov/pubmed/27087856 http://dx.doi.org/10.1186/s13072-016-0065-5 |