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Insulin Neuroprotection and the Mechanisms
OBJECTIVE: To analyze the mechanism of neuroprotection of insulin and which blood glucose range was benefit for insulin exerting neuroprotective action. DATA SOURCES: The study is based on the data from PubMed. STUDY SELECTION: Articles were selected with the search terms “insulin”, “blood glucose”,...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834017/ https://www.ncbi.nlm.nih.gov/pubmed/25836621 http://dx.doi.org/10.4103/0366-6999.154323 |
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author | Yu, Li-Yun Pei, Yu |
author_facet | Yu, Li-Yun Pei, Yu |
author_sort | Yu, Li-Yun |
collection | PubMed |
description | OBJECTIVE: To analyze the mechanism of neuroprotection of insulin and which blood glucose range was benefit for insulin exerting neuroprotective action. DATA SOURCES: The study is based on the data from PubMed. STUDY SELECTION: Articles were selected with the search terms “insulin”, “blood glucose”, “neuroprotection”, “brain”, “glycogen”, “cerebral ischemia”, “neuronal necrosis”, “glutamate”, “γ-aminobutyric acid”. RESULTS: Insulin has neuroprotection. The mechanisms include the regulation of neurotransmitter, promoting glycogen synthesis, and inhibition of neuronal necrosis and apoptosis. Insulin could play its role in neuroprotection by avoiding hypoglycemia and hyperglycemia. CONCLUSIONS: Intermittent and long-term infusion insulin may be a benefit for patients with ischemic brain damage at blood glucose 6–9 mmol/L. |
format | Online Article Text |
id | pubmed-4834017 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-48340172016-04-29 Insulin Neuroprotection and the Mechanisms Yu, Li-Yun Pei, Yu Chin Med J (Engl) Review Article OBJECTIVE: To analyze the mechanism of neuroprotection of insulin and which blood glucose range was benefit for insulin exerting neuroprotective action. DATA SOURCES: The study is based on the data from PubMed. STUDY SELECTION: Articles were selected with the search terms “insulin”, “blood glucose”, “neuroprotection”, “brain”, “glycogen”, “cerebral ischemia”, “neuronal necrosis”, “glutamate”, “γ-aminobutyric acid”. RESULTS: Insulin has neuroprotection. The mechanisms include the regulation of neurotransmitter, promoting glycogen synthesis, and inhibition of neuronal necrosis and apoptosis. Insulin could play its role in neuroprotection by avoiding hypoglycemia and hyperglycemia. CONCLUSIONS: Intermittent and long-term infusion insulin may be a benefit for patients with ischemic brain damage at blood glucose 6–9 mmol/L. Medknow Publications & Media Pvt Ltd 2015-04-05 /pmc/articles/PMC4834017/ /pubmed/25836621 http://dx.doi.org/10.4103/0366-6999.154323 Text en Copyright: © 2015 Chinese Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Yu, Li-Yun Pei, Yu Insulin Neuroprotection and the Mechanisms |
title | Insulin Neuroprotection and the Mechanisms |
title_full | Insulin Neuroprotection and the Mechanisms |
title_fullStr | Insulin Neuroprotection and the Mechanisms |
title_full_unstemmed | Insulin Neuroprotection and the Mechanisms |
title_short | Insulin Neuroprotection and the Mechanisms |
title_sort | insulin neuroprotection and the mechanisms |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834017/ https://www.ncbi.nlm.nih.gov/pubmed/25836621 http://dx.doi.org/10.4103/0366-6999.154323 |
work_keys_str_mv | AT yuliyun insulinneuroprotectionandthemechanisms AT peiyu insulinneuroprotectionandthemechanisms |