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Insulin Neuroprotection and the Mechanisms

OBJECTIVE: To analyze the mechanism of neuroprotection of insulin and which blood glucose range was benefit for insulin exerting neuroprotective action. DATA SOURCES: The study is based on the data from PubMed. STUDY SELECTION: Articles were selected with the search terms “insulin”, “blood glucose”,...

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Detalles Bibliográficos
Autores principales: Yu, Li-Yun, Pei, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834017/
https://www.ncbi.nlm.nih.gov/pubmed/25836621
http://dx.doi.org/10.4103/0366-6999.154323
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author Yu, Li-Yun
Pei, Yu
author_facet Yu, Li-Yun
Pei, Yu
author_sort Yu, Li-Yun
collection PubMed
description OBJECTIVE: To analyze the mechanism of neuroprotection of insulin and which blood glucose range was benefit for insulin exerting neuroprotective action. DATA SOURCES: The study is based on the data from PubMed. STUDY SELECTION: Articles were selected with the search terms “insulin”, “blood glucose”, “neuroprotection”, “brain”, “glycogen”, “cerebral ischemia”, “neuronal necrosis”, “glutamate”, “γ-aminobutyric acid”. RESULTS: Insulin has neuroprotection. The mechanisms include the regulation of neurotransmitter, promoting glycogen synthesis, and inhibition of neuronal necrosis and apoptosis. Insulin could play its role in neuroprotection by avoiding hypoglycemia and hyperglycemia. CONCLUSIONS: Intermittent and long-term infusion insulin may be a benefit for patients with ischemic brain damage at blood glucose 6–9 mmol/L.
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spelling pubmed-48340172016-04-29 Insulin Neuroprotection and the Mechanisms Yu, Li-Yun Pei, Yu Chin Med J (Engl) Review Article OBJECTIVE: To analyze the mechanism of neuroprotection of insulin and which blood glucose range was benefit for insulin exerting neuroprotective action. DATA SOURCES: The study is based on the data from PubMed. STUDY SELECTION: Articles were selected with the search terms “insulin”, “blood glucose”, “neuroprotection”, “brain”, “glycogen”, “cerebral ischemia”, “neuronal necrosis”, “glutamate”, “γ-aminobutyric acid”. RESULTS: Insulin has neuroprotection. The mechanisms include the regulation of neurotransmitter, promoting glycogen synthesis, and inhibition of neuronal necrosis and apoptosis. Insulin could play its role in neuroprotection by avoiding hypoglycemia and hyperglycemia. CONCLUSIONS: Intermittent and long-term infusion insulin may be a benefit for patients with ischemic brain damage at blood glucose 6–9 mmol/L. Medknow Publications & Media Pvt Ltd 2015-04-05 /pmc/articles/PMC4834017/ /pubmed/25836621 http://dx.doi.org/10.4103/0366-6999.154323 Text en Copyright: © 2015 Chinese Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.
spellingShingle Review Article
Yu, Li-Yun
Pei, Yu
Insulin Neuroprotection and the Mechanisms
title Insulin Neuroprotection and the Mechanisms
title_full Insulin Neuroprotection and the Mechanisms
title_fullStr Insulin Neuroprotection and the Mechanisms
title_full_unstemmed Insulin Neuroprotection and the Mechanisms
title_short Insulin Neuroprotection and the Mechanisms
title_sort insulin neuroprotection and the mechanisms
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834017/
https://www.ncbi.nlm.nih.gov/pubmed/25836621
http://dx.doi.org/10.4103/0366-6999.154323
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