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Childhood febrile illness and the risk of myopia in UK Biobank participants
PURPOSE: Historical reports suggest febrile illness during childhood is a risk factor for myopia. The establishment of the UK Biobank provided a unique opportunity to investigate this relationship. PATIENTS AND METHODS: We studied a sample of UK Biobank participants of White ethnicity aged 40–69 yea...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834038/ https://www.ncbi.nlm.nih.gov/pubmed/26846593 http://dx.doi.org/10.1038/eye.2016.7 |
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author | Guggenheim, J A Williams, C |
author_facet | Guggenheim, J A Williams, C |
author_sort | Guggenheim, J A |
collection | PubMed |
description | PURPOSE: Historical reports suggest febrile illness during childhood is a risk factor for myopia. The establishment of the UK Biobank provided a unique opportunity to investigate this relationship. PATIENTS AND METHODS: We studied a sample of UK Biobank participants of White ethnicity aged 40–69 years old who underwent autorefraction (N=91 592) and were classified as myopic (≤−0.75 Dioptres (D)), highly myopic (≤−6.00 D), or non-myopic (>−0.75 D). Self-reported age at diagnosis of past medical conditions was ascertained during an interview with a nurse at a Biobank assessment centre. Logistic regression analysis was used to calculate the odds ratio (OR) for myopia or high myopia associated with a diagnosis before age 17 years of each of nine febrile illnesses, after adjusting for potential confounders (age, sex, highest educational qualification, and birth order). RESULTS: Rubella, mumps, and pertussis were associated with myopia: rubella, OR=1.38, 95% CI: 1.03–1.85, P=0.030; mumps, OR=1.32, 95% CI: 1.07–1.64, P=0.010; and pertussis, OR=1.39, 95% CI 1.03–1.87, P=0.029. Measles, rubella, and pertussis were associated with high myopia: measles, OR=1.48, 95% CI: 1.07–2.07, P=0.019; rubella, OR=1.94, 95% CI: 1.12–3.35, P=0.017; and pertussis, OR=2.15, 95% CI: 1.24–3.71, P=0.006. The evidence did not support an interaction between education and febrile illness in explaining the above risks. CONCLUSION: A history of childhood measles, rubella, or pertussis was associated with high myopia, whereas a history of childhood rubella, mumps, or pertussis was associated with any myopia. The reasons for these associations are unclear. |
format | Online Article Text |
id | pubmed-4834038 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-48340382016-04-16 Childhood febrile illness and the risk of myopia in UK Biobank participants Guggenheim, J A Williams, C Eye (Lond) Clinical Study PURPOSE: Historical reports suggest febrile illness during childhood is a risk factor for myopia. The establishment of the UK Biobank provided a unique opportunity to investigate this relationship. PATIENTS AND METHODS: We studied a sample of UK Biobank participants of White ethnicity aged 40–69 years old who underwent autorefraction (N=91 592) and were classified as myopic (≤−0.75 Dioptres (D)), highly myopic (≤−6.00 D), or non-myopic (>−0.75 D). Self-reported age at diagnosis of past medical conditions was ascertained during an interview with a nurse at a Biobank assessment centre. Logistic regression analysis was used to calculate the odds ratio (OR) for myopia or high myopia associated with a diagnosis before age 17 years of each of nine febrile illnesses, after adjusting for potential confounders (age, sex, highest educational qualification, and birth order). RESULTS: Rubella, mumps, and pertussis were associated with myopia: rubella, OR=1.38, 95% CI: 1.03–1.85, P=0.030; mumps, OR=1.32, 95% CI: 1.07–1.64, P=0.010; and pertussis, OR=1.39, 95% CI 1.03–1.87, P=0.029. Measles, rubella, and pertussis were associated with high myopia: measles, OR=1.48, 95% CI: 1.07–2.07, P=0.019; rubella, OR=1.94, 95% CI: 1.12–3.35, P=0.017; and pertussis, OR=2.15, 95% CI: 1.24–3.71, P=0.006. The evidence did not support an interaction between education and febrile illness in explaining the above risks. CONCLUSION: A history of childhood measles, rubella, or pertussis was associated with high myopia, whereas a history of childhood rubella, mumps, or pertussis was associated with any myopia. The reasons for these associations are unclear. Nature Publishing Group 2016-04 2016-02-05 /pmc/articles/PMC4834038/ /pubmed/26846593 http://dx.doi.org/10.1038/eye.2016.7 Text en Copyright © 2016 Royal College of Ophthalmologists http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Clinical Study Guggenheim, J A Williams, C Childhood febrile illness and the risk of myopia in UK Biobank participants |
title | Childhood febrile illness and the risk of myopia in UK Biobank participants |
title_full | Childhood febrile illness and the risk of myopia in UK Biobank participants |
title_fullStr | Childhood febrile illness and the risk of myopia in UK Biobank participants |
title_full_unstemmed | Childhood febrile illness and the risk of myopia in UK Biobank participants |
title_short | Childhood febrile illness and the risk of myopia in UK Biobank participants |
title_sort | childhood febrile illness and the risk of myopia in uk biobank participants |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834038/ https://www.ncbi.nlm.nih.gov/pubmed/26846593 http://dx.doi.org/10.1038/eye.2016.7 |
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