Translational Pharmacokinetic‐Pharmacodynamic Modeling and Simulation: Optimizing 5‐Fluorouracil Dosing in Children With Pediatric Ependymoma

We previously investigated novel therapies for pediatric ependymoma and found 5‐fluorouracil (5‐FU) i.v. bolus increased survival in a representative mouse model. However, without a quantitative framework to derive clinical dosing recommendations, we devised a translational pharmacokinetic‐pharmacod...

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Detalles Bibliográficos
Autores principales: Daryani, VM, Patel, YT, Tagen, M, Turner, DC, Carcaboso, AM, Atkinson, JM, Gajjar, A, Gilbertson, RJ, Wright, KD, Stewart, CF
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834132/
https://www.ncbi.nlm.nih.gov/pubmed/27104090
http://dx.doi.org/10.1002/psp4.12075

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