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Considerations for MRI study design and implementation in pediatric and clinical populations

Human neuroimaging, specifically magnetic resonance imaging (MRI), is being used with increasing popularity to study brain structure and function in development and disease. When applying these methods to developmental and clinical populations, careful consideration must be taken with regard to stud...

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Detalles Bibliográficos
Autores principales: Greene, Deanna J., Black, Kevin J., Schlaggar, Bradley L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834255/
https://www.ncbi.nlm.nih.gov/pubmed/26754461
http://dx.doi.org/10.1016/j.dcn.2015.12.005
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author Greene, Deanna J.
Black, Kevin J.
Schlaggar, Bradley L.
author_facet Greene, Deanna J.
Black, Kevin J.
Schlaggar, Bradley L.
author_sort Greene, Deanna J.
collection PubMed
description Human neuroimaging, specifically magnetic resonance imaging (MRI), is being used with increasing popularity to study brain structure and function in development and disease. When applying these methods to developmental and clinical populations, careful consideration must be taken with regard to study design and implementation. In this article, we discuss two major considerations particularly pertinent to brain research in special populations. First, we discuss considerations for subject selection and characterization, including issues related to comorbid conditions, medication status, and clinical assessment. Second, we discuss methods and considerations for acquisition of adequate, useable MRI data. Given that children and patients may experience anxiety with the scanner environment, preventing participation, and that they have a higher risk of motion artifact, resulting in data loss, successful subject compliance and data acquisition are not trivial tasks. We conclude that, as researchers, we must consider a number of issues when using neuroimaging tools to study children and patients, and we should thoughtfully justify our choices of methods and study design.
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spelling pubmed-48342552016-04-21 Considerations for MRI study design and implementation in pediatric and clinical populations Greene, Deanna J. Black, Kevin J. Schlaggar, Bradley L. Dev Cogn Neurosci Original Research Human neuroimaging, specifically magnetic resonance imaging (MRI), is being used with increasing popularity to study brain structure and function in development and disease. When applying these methods to developmental and clinical populations, careful consideration must be taken with regard to study design and implementation. In this article, we discuss two major considerations particularly pertinent to brain research in special populations. First, we discuss considerations for subject selection and characterization, including issues related to comorbid conditions, medication status, and clinical assessment. Second, we discuss methods and considerations for acquisition of adequate, useable MRI data. Given that children and patients may experience anxiety with the scanner environment, preventing participation, and that they have a higher risk of motion artifact, resulting in data loss, successful subject compliance and data acquisition are not trivial tasks. We conclude that, as researchers, we must consider a number of issues when using neuroimaging tools to study children and patients, and we should thoughtfully justify our choices of methods and study design. Elsevier 2015-12-17 /pmc/articles/PMC4834255/ /pubmed/26754461 http://dx.doi.org/10.1016/j.dcn.2015.12.005 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Research
Greene, Deanna J.
Black, Kevin J.
Schlaggar, Bradley L.
Considerations for MRI study design and implementation in pediatric and clinical populations
title Considerations for MRI study design and implementation in pediatric and clinical populations
title_full Considerations for MRI study design and implementation in pediatric and clinical populations
title_fullStr Considerations for MRI study design and implementation in pediatric and clinical populations
title_full_unstemmed Considerations for MRI study design and implementation in pediatric and clinical populations
title_short Considerations for MRI study design and implementation in pediatric and clinical populations
title_sort considerations for mri study design and implementation in pediatric and clinical populations
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834255/
https://www.ncbi.nlm.nih.gov/pubmed/26754461
http://dx.doi.org/10.1016/j.dcn.2015.12.005
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