HERC 1 Ubiquitin Ligase Mutation Affects Neocortical, CA3 Hippocampal and Spinal Cord Projection Neurons: An Ultrastructural Study

The spontaneous mutation tambaleante is caused by the Gly483Glu substitution in the highly conserved N terminal RCC1-like domain of the HERC1 protein, which leads to the increase of mutated protein levels responsible for cerebellar Purkinje cell death by autophagy. Until now, Purkinje cells have bee...

Descripción completa

Detalles Bibliográficos
Autores principales: Ruiz, Rocío, Pérez-Villegas, Eva María, Bachiller, Sara, Rosa, José Luis, Armengol, José Angel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834294/
https://www.ncbi.nlm.nih.gov/pubmed/27147983
http://dx.doi.org/10.3389/fnana.2016.00042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834294/
https://www.ncbi.nlm.nih.gov/pubmed/27147983
http://dx.doi.org/10.3389/fnana.2016.00042

Ejemplares similares