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Genetic variation in bitter taste receptor genes influences the foraging behavior of plateau zokor (Eospalax baileyi)
The ability to detect bitter tastes is important for animals; it can help them to avoid ingesting harmful substances. Bitter taste perception is mainly mediated by bitter taste receptor proteins, which are encoded by members of the Tas2r gene family and vary with the dietary preference of a specific...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834321/ https://www.ncbi.nlm.nih.gov/pubmed/27110349 http://dx.doi.org/10.1002/ece3.2041 |
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author | Zhao, Fang Zhang, Tongzuo Xie, Jiuxiang Zhang, Shoudong Nevo, Eviatar Su, Jianping Lin, Gonghua |
author_facet | Zhao, Fang Zhang, Tongzuo Xie, Jiuxiang Zhang, Shoudong Nevo, Eviatar Su, Jianping Lin, Gonghua |
author_sort | Zhao, Fang |
collection | PubMed |
description | The ability to detect bitter tastes is important for animals; it can help them to avoid ingesting harmful substances. Bitter taste perception is mainly mediated by bitter taste receptor proteins, which are encoded by members of the Tas2r gene family and vary with the dietary preference of a specific species. Although individuals with different genotypes differ in bitterness recognition capability, little is known about the relationship between genetic variation and food selection tendencies at the intraspecific level. In this study, we examined the relationship between genotypes and diet in plateau zokor (Eospalax baileyi), a subterranean rodent endemic to the Qinghai‐Tibet Plateau that caches food for the winter. We assayed the composition and taste profile of each plant contained in temporary caches and vicinity quadrats, which were representative of selected and available food, respectively. Bitter plant selection indices (E (bitter)) were estimated. We also sequenced 26 candidate Tas2r genes from zokors and determined their relationships with the E (bitter) of their caches. We identified four key results: (1) zokors varied considerably in both bitter food preference and Tas2r sequences; (2) five genes (zTas2r115,zTas2r119,zTas2r126,zTas2r134, and zTas2r136) exhibited allelic variation that was significantly associated with E (bitter); (3) synonymous SNPs, nonsynonymous SNPs, and pseudogenization are involved in the genotype–phenotype relationship; (4) the minor genotypes of zTas2r115,zTas2r134, and zTas2r136 and the major genotypes of zTas2r119 and zTas2r126 cached more bitter plants. Our results link Tas2r variation with food selection behavior at the population level for the first time. |
format | Online Article Text |
id | pubmed-4834321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-48343212016-04-22 Genetic variation in bitter taste receptor genes influences the foraging behavior of plateau zokor (Eospalax baileyi) Zhao, Fang Zhang, Tongzuo Xie, Jiuxiang Zhang, Shoudong Nevo, Eviatar Su, Jianping Lin, Gonghua Ecol Evol Original Research The ability to detect bitter tastes is important for animals; it can help them to avoid ingesting harmful substances. Bitter taste perception is mainly mediated by bitter taste receptor proteins, which are encoded by members of the Tas2r gene family and vary with the dietary preference of a specific species. Although individuals with different genotypes differ in bitterness recognition capability, little is known about the relationship between genetic variation and food selection tendencies at the intraspecific level. In this study, we examined the relationship between genotypes and diet in plateau zokor (Eospalax baileyi), a subterranean rodent endemic to the Qinghai‐Tibet Plateau that caches food for the winter. We assayed the composition and taste profile of each plant contained in temporary caches and vicinity quadrats, which were representative of selected and available food, respectively. Bitter plant selection indices (E (bitter)) were estimated. We also sequenced 26 candidate Tas2r genes from zokors and determined their relationships with the E (bitter) of their caches. We identified four key results: (1) zokors varied considerably in both bitter food preference and Tas2r sequences; (2) five genes (zTas2r115,zTas2r119,zTas2r126,zTas2r134, and zTas2r136) exhibited allelic variation that was significantly associated with E (bitter); (3) synonymous SNPs, nonsynonymous SNPs, and pseudogenization are involved in the genotype–phenotype relationship; (4) the minor genotypes of zTas2r115,zTas2r134, and zTas2r136 and the major genotypes of zTas2r119 and zTas2r126 cached more bitter plants. Our results link Tas2r variation with food selection behavior at the population level for the first time. John Wiley and Sons Inc. 2016-03-06 /pmc/articles/PMC4834321/ /pubmed/27110349 http://dx.doi.org/10.1002/ece3.2041 Text en © 2016 The Authors. Ecology and Evolution published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Zhao, Fang Zhang, Tongzuo Xie, Jiuxiang Zhang, Shoudong Nevo, Eviatar Su, Jianping Lin, Gonghua Genetic variation in bitter taste receptor genes influences the foraging behavior of plateau zokor (Eospalax baileyi) |
title | Genetic variation in bitter taste receptor genes influences the foraging behavior of plateau zokor (Eospalax baileyi) |
title_full | Genetic variation in bitter taste receptor genes influences the foraging behavior of plateau zokor (Eospalax baileyi) |
title_fullStr | Genetic variation in bitter taste receptor genes influences the foraging behavior of plateau zokor (Eospalax baileyi) |
title_full_unstemmed | Genetic variation in bitter taste receptor genes influences the foraging behavior of plateau zokor (Eospalax baileyi) |
title_short | Genetic variation in bitter taste receptor genes influences the foraging behavior of plateau zokor (Eospalax baileyi) |
title_sort | genetic variation in bitter taste receptor genes influences the foraging behavior of plateau zokor (eospalax baileyi) |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834321/ https://www.ncbi.nlm.nih.gov/pubmed/27110349 http://dx.doi.org/10.1002/ece3.2041 |
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