Cargando…
The Three Paralogous MicroRNA Clusters in Development and Disease, miR-17-92, miR-106a-363, and miR-106b-25
MicroRNAs (miRNAs) form a class of noncoding RNA genes whose products are small single-stranded RNAs that are involved in the regulation of translation and degradation of mRNAs. There is a fine balance between deregulation of normal developmental programs and tumor genesis. An increasing body of evi...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834410/ https://www.ncbi.nlm.nih.gov/pubmed/27127675 http://dx.doi.org/10.1155/2016/1379643 |
_version_ | 1782427481644466176 |
---|---|
author | Khuu, Cuong Utheim, Tor Paaske Sehic, Amer |
author_facet | Khuu, Cuong Utheim, Tor Paaske Sehic, Amer |
author_sort | Khuu, Cuong |
collection | PubMed |
description | MicroRNAs (miRNAs) form a class of noncoding RNA genes whose products are small single-stranded RNAs that are involved in the regulation of translation and degradation of mRNAs. There is a fine balance between deregulation of normal developmental programs and tumor genesis. An increasing body of evidence suggests that altered expression of miRNAs is entailed in the pathogenesis of human cancers. Studies in mouse and human cells have identified the miR-17-92 cluster as a potential oncogene. The miR-17-92 cluster is often amplified or overexpressed in human cancers and has recently emerged as the prototypical oncogenic polycistron miRNA. The functional analysis of miR-17-92 is intricate by the existence of two paralogues: miR-106a-363 and miR-106b-25. During early evolution of vertebrates, it is likely that the three clusters commenced via a series of duplication and deletion occurrences. As miR-106a-363 and miR-106b-25 contain miRNAs that are very similar, and in some cases identical, to those encoded by miR-17-92, it is feasible that they regulate a similar set of genes and have overlapping functions. Further understanding of these three clusters and their functions will increase our knowledge about cancer progression. The present review discusses the characteristics and functions of these three miRNA clusters. |
format | Online Article Text |
id | pubmed-4834410 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-48344102016-04-28 The Three Paralogous MicroRNA Clusters in Development and Disease, miR-17-92, miR-106a-363, and miR-106b-25 Khuu, Cuong Utheim, Tor Paaske Sehic, Amer Scientifica (Cairo) Review Article MicroRNAs (miRNAs) form a class of noncoding RNA genes whose products are small single-stranded RNAs that are involved in the regulation of translation and degradation of mRNAs. There is a fine balance between deregulation of normal developmental programs and tumor genesis. An increasing body of evidence suggests that altered expression of miRNAs is entailed in the pathogenesis of human cancers. Studies in mouse and human cells have identified the miR-17-92 cluster as a potential oncogene. The miR-17-92 cluster is often amplified or overexpressed in human cancers and has recently emerged as the prototypical oncogenic polycistron miRNA. The functional analysis of miR-17-92 is intricate by the existence of two paralogues: miR-106a-363 and miR-106b-25. During early evolution of vertebrates, it is likely that the three clusters commenced via a series of duplication and deletion occurrences. As miR-106a-363 and miR-106b-25 contain miRNAs that are very similar, and in some cases identical, to those encoded by miR-17-92, it is feasible that they regulate a similar set of genes and have overlapping functions. Further understanding of these three clusters and their functions will increase our knowledge about cancer progression. The present review discusses the characteristics and functions of these three miRNA clusters. Hindawi Publishing Corporation 2016 2016-04-04 /pmc/articles/PMC4834410/ /pubmed/27127675 http://dx.doi.org/10.1155/2016/1379643 Text en Copyright © 2016 Cuong Khuu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Khuu, Cuong Utheim, Tor Paaske Sehic, Amer The Three Paralogous MicroRNA Clusters in Development and Disease, miR-17-92, miR-106a-363, and miR-106b-25 |
title | The Three Paralogous MicroRNA Clusters in Development and Disease, miR-17-92, miR-106a-363, and miR-106b-25 |
title_full | The Three Paralogous MicroRNA Clusters in Development and Disease, miR-17-92, miR-106a-363, and miR-106b-25 |
title_fullStr | The Three Paralogous MicroRNA Clusters in Development and Disease, miR-17-92, miR-106a-363, and miR-106b-25 |
title_full_unstemmed | The Three Paralogous MicroRNA Clusters in Development and Disease, miR-17-92, miR-106a-363, and miR-106b-25 |
title_short | The Three Paralogous MicroRNA Clusters in Development and Disease, miR-17-92, miR-106a-363, and miR-106b-25 |
title_sort | three paralogous microrna clusters in development and disease, mir-17-92, mir-106a-363, and mir-106b-25 |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834410/ https://www.ncbi.nlm.nih.gov/pubmed/27127675 http://dx.doi.org/10.1155/2016/1379643 |
work_keys_str_mv | AT khuucuong thethreeparalogousmicrornaclustersindevelopmentanddiseasemir1792mir106a363andmir106b25 AT utheimtorpaaske thethreeparalogousmicrornaclustersindevelopmentanddiseasemir1792mir106a363andmir106b25 AT sehicamer thethreeparalogousmicrornaclustersindevelopmentanddiseasemir1792mir106a363andmir106b25 AT khuucuong threeparalogousmicrornaclustersindevelopmentanddiseasemir1792mir106a363andmir106b25 AT utheimtorpaaske threeparalogousmicrornaclustersindevelopmentanddiseasemir1792mir106a363andmir106b25 AT sehicamer threeparalogousmicrornaclustersindevelopmentanddiseasemir1792mir106a363andmir106b25 |