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Likelihood of mechanistic roles for dopaminergic, serotonergic and glutamatergic receptors in tardive dyskinesia: A comparison of genetic variants in two independent patient populations

OBJECTIVES: An established theory for the pathogenesis of tardive dyskinesia is disturbed dopaminergic receptor sensitivity and/or dopaminergic intracellular signaling. We examined associations between genetic variants of neurotransmitter receptors and tardive dyskinesia. METHODS: We assessed tardiv...

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Autores principales: Ivanova, Svetlana A, Loonen, Anton JM, Bakker, P Roberto, Freidin, Maxim B, ter Woerds, Nienke J, Al Hadithy, Asmar FY, Semke, Arkadiy V, Fedorenko, Olga Yu, Brouwers, Jacobus RBJ, Bokhan, Nikolay A, van Os, Jim, van Harten, Peter N, Wilffert, Bob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834466/
https://www.ncbi.nlm.nih.gov/pubmed/27127627
http://dx.doi.org/10.1177/2050312116643673
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author Ivanova, Svetlana A
Loonen, Anton JM
Bakker, P Roberto
Freidin, Maxim B
ter Woerds, Nienke J
Al Hadithy, Asmar FY
Semke, Arkadiy V
Fedorenko, Olga Yu
Brouwers, Jacobus RBJ
Bokhan, Nikolay A
van Os, Jim
van Harten, Peter N
Wilffert, Bob
author_facet Ivanova, Svetlana A
Loonen, Anton JM
Bakker, P Roberto
Freidin, Maxim B
ter Woerds, Nienke J
Al Hadithy, Asmar FY
Semke, Arkadiy V
Fedorenko, Olga Yu
Brouwers, Jacobus RBJ
Bokhan, Nikolay A
van Os, Jim
van Harten, Peter N
Wilffert, Bob
author_sort Ivanova, Svetlana A
collection PubMed
description OBJECTIVES: An established theory for the pathogenesis of tardive dyskinesia is disturbed dopaminergic receptor sensitivity and/or dopaminergic intracellular signaling. We examined associations between genetic variants of neurotransmitter receptors and tardive dyskinesia. METHODS: We assessed tardive dyskinesia in Caucasian psychiatric inpatients from Siberia (N = 431) and a long-stay population from the Netherlands (N = 168). These patients were genotyped for 43 tag single nucleotide polymorphisms in five neurotransmitter receptor genes, and the results for the two populations were compared. RESULTS: Several significant associations with tardive dyskinesia were identified, but only GRIN2A (rs1345423) was found in both patient populations. This lack of agreement was probably due to the small effect size of the associations, the multiple testing and the small sample size of the Dutch patient population. After reviewing the literature, we propose that the constitutive stimulatory activity of serotonergic type 2 receptors may be relevant. CONCLUSIONS: Inactivity of the serotonergic, type 2C receptor or blockade of these receptors by atypical antipsychotic drugs may decrease the vulnerability to develop tardive dyskinesia.
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spelling pubmed-48344662016-04-28 Likelihood of mechanistic roles for dopaminergic, serotonergic and glutamatergic receptors in tardive dyskinesia: A comparison of genetic variants in two independent patient populations Ivanova, Svetlana A Loonen, Anton JM Bakker, P Roberto Freidin, Maxim B ter Woerds, Nienke J Al Hadithy, Asmar FY Semke, Arkadiy V Fedorenko, Olga Yu Brouwers, Jacobus RBJ Bokhan, Nikolay A van Os, Jim van Harten, Peter N Wilffert, Bob SAGE Open Med Original Article OBJECTIVES: An established theory for the pathogenesis of tardive dyskinesia is disturbed dopaminergic receptor sensitivity and/or dopaminergic intracellular signaling. We examined associations between genetic variants of neurotransmitter receptors and tardive dyskinesia. METHODS: We assessed tardive dyskinesia in Caucasian psychiatric inpatients from Siberia (N = 431) and a long-stay population from the Netherlands (N = 168). These patients were genotyped for 43 tag single nucleotide polymorphisms in five neurotransmitter receptor genes, and the results for the two populations were compared. RESULTS: Several significant associations with tardive dyskinesia were identified, but only GRIN2A (rs1345423) was found in both patient populations. This lack of agreement was probably due to the small effect size of the associations, the multiple testing and the small sample size of the Dutch patient population. After reviewing the literature, we propose that the constitutive stimulatory activity of serotonergic type 2 receptors may be relevant. CONCLUSIONS: Inactivity of the serotonergic, type 2C receptor or blockade of these receptors by atypical antipsychotic drugs may decrease the vulnerability to develop tardive dyskinesia. SAGE Publications 2016-04-11 /pmc/articles/PMC4834466/ /pubmed/27127627 http://dx.doi.org/10.1177/2050312116643673 Text en © The Author(s) 2016 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Article
Ivanova, Svetlana A
Loonen, Anton JM
Bakker, P Roberto
Freidin, Maxim B
ter Woerds, Nienke J
Al Hadithy, Asmar FY
Semke, Arkadiy V
Fedorenko, Olga Yu
Brouwers, Jacobus RBJ
Bokhan, Nikolay A
van Os, Jim
van Harten, Peter N
Wilffert, Bob
Likelihood of mechanistic roles for dopaminergic, serotonergic and glutamatergic receptors in tardive dyskinesia: A comparison of genetic variants in two independent patient populations
title Likelihood of mechanistic roles for dopaminergic, serotonergic and glutamatergic receptors in tardive dyskinesia: A comparison of genetic variants in two independent patient populations
title_full Likelihood of mechanistic roles for dopaminergic, serotonergic and glutamatergic receptors in tardive dyskinesia: A comparison of genetic variants in two independent patient populations
title_fullStr Likelihood of mechanistic roles for dopaminergic, serotonergic and glutamatergic receptors in tardive dyskinesia: A comparison of genetic variants in two independent patient populations
title_full_unstemmed Likelihood of mechanistic roles for dopaminergic, serotonergic and glutamatergic receptors in tardive dyskinesia: A comparison of genetic variants in two independent patient populations
title_short Likelihood of mechanistic roles for dopaminergic, serotonergic and glutamatergic receptors in tardive dyskinesia: A comparison of genetic variants in two independent patient populations
title_sort likelihood of mechanistic roles for dopaminergic, serotonergic and glutamatergic receptors in tardive dyskinesia: a comparison of genetic variants in two independent patient populations
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834466/
https://www.ncbi.nlm.nih.gov/pubmed/27127627
http://dx.doi.org/10.1177/2050312116643673
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