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Leishmania Infection Engages Non-Receptor Protein Kinases Differentially to Persist in Infected Hosts

Protein kinases play important roles in the regulation of cellular activities. In cells infected by pathogens, there is an increasing appreciation that dysregulated expression of protein kinases promotes the success of intracellular infections. In Leishmania-infected cells, expression and activation...

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Autores principales: Zhang, Naixin, Kima, Peter E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834468/
https://www.ncbi.nlm.nih.gov/pubmed/27148265
http://dx.doi.org/10.3389/fimmu.2016.00146
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author Zhang, Naixin
Kima, Peter E.
author_facet Zhang, Naixin
Kima, Peter E.
author_sort Zhang, Naixin
collection PubMed
description Protein kinases play important roles in the regulation of cellular activities. In cells infected by pathogens, there is an increasing appreciation that dysregulated expression of protein kinases promotes the success of intracellular infections. In Leishmania-infected cells, expression and activation of protein kinases, such as the mitogen-activated protein kinases, kinases in the PI3-kinase signaling pathway, and kinases in the NF-κB-signaling pathway, are modulated in some manner. Several recent reviews have discussed our current understanding of the roles of these kinases in Leishmania infections. Apart from the kinases in the pathways enumerated above, there are other host cell protein kinases that are activated during the Leishmania infection of mammalian cells whose roles also appear to be significant. This review discusses recent observations on the Abl family of protein kinases and the protein kinase regulated by RNA in Leishmania infections.
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spelling pubmed-48344682016-05-04 Leishmania Infection Engages Non-Receptor Protein Kinases Differentially to Persist in Infected Hosts Zhang, Naixin Kima, Peter E. Front Immunol Immunology Protein kinases play important roles in the regulation of cellular activities. In cells infected by pathogens, there is an increasing appreciation that dysregulated expression of protein kinases promotes the success of intracellular infections. In Leishmania-infected cells, expression and activation of protein kinases, such as the mitogen-activated protein kinases, kinases in the PI3-kinase signaling pathway, and kinases in the NF-κB-signaling pathway, are modulated in some manner. Several recent reviews have discussed our current understanding of the roles of these kinases in Leishmania infections. Apart from the kinases in the pathways enumerated above, there are other host cell protein kinases that are activated during the Leishmania infection of mammalian cells whose roles also appear to be significant. This review discusses recent observations on the Abl family of protein kinases and the protein kinase regulated by RNA in Leishmania infections. Frontiers Media S.A. 2016-04-18 /pmc/articles/PMC4834468/ /pubmed/27148265 http://dx.doi.org/10.3389/fimmu.2016.00146 Text en Copyright © 2016 Zhang and Kima. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Zhang, Naixin
Kima, Peter E.
Leishmania Infection Engages Non-Receptor Protein Kinases Differentially to Persist in Infected Hosts
title Leishmania Infection Engages Non-Receptor Protein Kinases Differentially to Persist in Infected Hosts
title_full Leishmania Infection Engages Non-Receptor Protein Kinases Differentially to Persist in Infected Hosts
title_fullStr Leishmania Infection Engages Non-Receptor Protein Kinases Differentially to Persist in Infected Hosts
title_full_unstemmed Leishmania Infection Engages Non-Receptor Protein Kinases Differentially to Persist in Infected Hosts
title_short Leishmania Infection Engages Non-Receptor Protein Kinases Differentially to Persist in Infected Hosts
title_sort leishmania infection engages non-receptor protein kinases differentially to persist in infected hosts
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834468/
https://www.ncbi.nlm.nih.gov/pubmed/27148265
http://dx.doi.org/10.3389/fimmu.2016.00146
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