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Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer

AIMS: Use of the anti‐tumour antibiotic actinomycin D is associated with development of hepatotoxicity, particularly in young children. A paucity of actinomycin D pharmacokinetic data make it challenging to develop a sound rationale for defining dosing regimens in younger patients. The study aim was...

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Detalles Bibliográficos
Autores principales:	Walsh, Christopher, Bonner, Jennifer J., Johnson, Trevor N., Neuhoff, Sibylle, Ghazaly, Essam A., Gribben, John G., Boddy, Alan V., Veal, Gareth J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Paediatric Clinical Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834588/ https://www.ncbi.nlm.nih.gov/pubmed/26727248 http://dx.doi.org/10.1111/bcp.12878

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