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Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response
Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is one of the four subtypes of gastric carcinoma (GC), as defined by the novel classification recently proposed by The Cancer Genome Atlas. EBVaGC has several clinicopathological features such as longer survival and higher frequency of lymphoe...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Gastric Cancer Association
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834615/ https://www.ncbi.nlm.nih.gov/pubmed/27104020 http://dx.doi.org/10.5230/jgc.2016.16.1.1 |
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author | Cho, Junhun Kang, Myung-Soo Kim, Kyoung-Mee |
author_facet | Cho, Junhun Kang, Myung-Soo Kim, Kyoung-Mee |
author_sort | Cho, Junhun |
collection | PubMed |
description | Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is one of the four subtypes of gastric carcinoma (GC), as defined by the novel classification recently proposed by The Cancer Genome Atlas. EBVaGC has several clinicopathological features such as longer survival and higher frequency of lymphoepithelioma-like carcinoma (LELC) and carcinoma with Crohn's disease-like lymphoid reaction that distinguish it from EBV-negative GC. The intensity and pattern of host cellular immune response in GC have been found to significantly correlate with the prognosis of patients with GC, suggesting that immune reaction and tumor microenvironment have critical roles in the progression of GC, and in particular, EBVaGC. Here, we reviewed the cellular and molecular mechanisms underlying prominent immune reactions in patients with EBVaGC. In EBVaGC, deregulation of the expression of immune response-related genes promotes marked intra- or peritumoral immune cell infiltration. The expression of programmed death receptor-ligand 1 is known to be increased in EBVaGC, and therefore, it has been proposed as a favorable prognostic factor for patients with EBVaGC, albeit some data supporting this claim are controversial. Overall, the underlying mechanisms and clinical significance of the host cellular immune response in patients with EBVaGC have not been thoroughly elucidated. Therefore, further research is necessary to better understand the role of tumor microenvironment in EBVaGC. |
format | Online Article Text |
id | pubmed-4834615 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | The Korean Gastric Cancer Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-48346152016-04-21 Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response Cho, Junhun Kang, Myung-Soo Kim, Kyoung-Mee J Gastric Cancer Review Article Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is one of the four subtypes of gastric carcinoma (GC), as defined by the novel classification recently proposed by The Cancer Genome Atlas. EBVaGC has several clinicopathological features such as longer survival and higher frequency of lymphoepithelioma-like carcinoma (LELC) and carcinoma with Crohn's disease-like lymphoid reaction that distinguish it from EBV-negative GC. The intensity and pattern of host cellular immune response in GC have been found to significantly correlate with the prognosis of patients with GC, suggesting that immune reaction and tumor microenvironment have critical roles in the progression of GC, and in particular, EBVaGC. Here, we reviewed the cellular and molecular mechanisms underlying prominent immune reactions in patients with EBVaGC. In EBVaGC, deregulation of the expression of immune response-related genes promotes marked intra- or peritumoral immune cell infiltration. The expression of programmed death receptor-ligand 1 is known to be increased in EBVaGC, and therefore, it has been proposed as a favorable prognostic factor for patients with EBVaGC, albeit some data supporting this claim are controversial. Overall, the underlying mechanisms and clinical significance of the host cellular immune response in patients with EBVaGC have not been thoroughly elucidated. Therefore, further research is necessary to better understand the role of tumor microenvironment in EBVaGC. The Korean Gastric Cancer Association 2016-03 2016-03-31 /pmc/articles/PMC4834615/ /pubmed/27104020 http://dx.doi.org/10.5230/jgc.2016.16.1.1 Text en Copyright © 2016 by The Korean Gastric Cancer Association http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Cho, Junhun Kang, Myung-Soo Kim, Kyoung-Mee Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response |
title | Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response |
title_full | Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response |
title_fullStr | Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response |
title_full_unstemmed | Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response |
title_short | Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response |
title_sort | epstein-barr virus-associated gastric carcinoma and specific features of the accompanying immune response |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834615/ https://www.ncbi.nlm.nih.gov/pubmed/27104020 http://dx.doi.org/10.5230/jgc.2016.16.1.1 |
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