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Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response

Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is one of the four subtypes of gastric carcinoma (GC), as defined by the novel classification recently proposed by The Cancer Genome Atlas. EBVaGC has several clinicopathological features such as longer survival and higher frequency of lymphoe...

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Autores principales: Cho, Junhun, Kang, Myung-Soo, Kim, Kyoung-Mee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Gastric Cancer Association 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834615/
https://www.ncbi.nlm.nih.gov/pubmed/27104020
http://dx.doi.org/10.5230/jgc.2016.16.1.1
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author Cho, Junhun
Kang, Myung-Soo
Kim, Kyoung-Mee
author_facet Cho, Junhun
Kang, Myung-Soo
Kim, Kyoung-Mee
author_sort Cho, Junhun
collection PubMed
description Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is one of the four subtypes of gastric carcinoma (GC), as defined by the novel classification recently proposed by The Cancer Genome Atlas. EBVaGC has several clinicopathological features such as longer survival and higher frequency of lymphoepithelioma-like carcinoma (LELC) and carcinoma with Crohn's disease-like lymphoid reaction that distinguish it from EBV-negative GC. The intensity and pattern of host cellular immune response in GC have been found to significantly correlate with the prognosis of patients with GC, suggesting that immune reaction and tumor microenvironment have critical roles in the progression of GC, and in particular, EBVaGC. Here, we reviewed the cellular and molecular mechanisms underlying prominent immune reactions in patients with EBVaGC. In EBVaGC, deregulation of the expression of immune response-related genes promotes marked intra- or peritumoral immune cell infiltration. The expression of programmed death receptor-ligand 1 is known to be increased in EBVaGC, and therefore, it has been proposed as a favorable prognostic factor for patients with EBVaGC, albeit some data supporting this claim are controversial. Overall, the underlying mechanisms and clinical significance of the host cellular immune response in patients with EBVaGC have not been thoroughly elucidated. Therefore, further research is necessary to better understand the role of tumor microenvironment in EBVaGC.
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spelling pubmed-48346152016-04-21 Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response Cho, Junhun Kang, Myung-Soo Kim, Kyoung-Mee J Gastric Cancer Review Article Epstein-Barr virus-associated gastric carcinoma (EBVaGC) is one of the four subtypes of gastric carcinoma (GC), as defined by the novel classification recently proposed by The Cancer Genome Atlas. EBVaGC has several clinicopathological features such as longer survival and higher frequency of lymphoepithelioma-like carcinoma (LELC) and carcinoma with Crohn's disease-like lymphoid reaction that distinguish it from EBV-negative GC. The intensity and pattern of host cellular immune response in GC have been found to significantly correlate with the prognosis of patients with GC, suggesting that immune reaction and tumor microenvironment have critical roles in the progression of GC, and in particular, EBVaGC. Here, we reviewed the cellular and molecular mechanisms underlying prominent immune reactions in patients with EBVaGC. In EBVaGC, deregulation of the expression of immune response-related genes promotes marked intra- or peritumoral immune cell infiltration. The expression of programmed death receptor-ligand 1 is known to be increased in EBVaGC, and therefore, it has been proposed as a favorable prognostic factor for patients with EBVaGC, albeit some data supporting this claim are controversial. Overall, the underlying mechanisms and clinical significance of the host cellular immune response in patients with EBVaGC have not been thoroughly elucidated. Therefore, further research is necessary to better understand the role of tumor microenvironment in EBVaGC. The Korean Gastric Cancer Association 2016-03 2016-03-31 /pmc/articles/PMC4834615/ /pubmed/27104020 http://dx.doi.org/10.5230/jgc.2016.16.1.1 Text en Copyright © 2016 by The Korean Gastric Cancer Association http://creativecommons.org/licenses/by-nc/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cho, Junhun
Kang, Myung-Soo
Kim, Kyoung-Mee
Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response
title Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response
title_full Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response
title_fullStr Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response
title_full_unstemmed Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response
title_short Epstein-Barr Virus-Associated Gastric Carcinoma and Specific Features of the Accompanying Immune Response
title_sort epstein-barr virus-associated gastric carcinoma and specific features of the accompanying immune response
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834615/
https://www.ncbi.nlm.nih.gov/pubmed/27104020
http://dx.doi.org/10.5230/jgc.2016.16.1.1
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