Antimalarial and antimicrobial activities of 8-Aminoquinoline-Uracils metal complexes

8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and antimicrobial agents. Interestingly, all of the...

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Detalles Bibliográficos
Autores principales: Phopin, Kamonrat, Sinthupoom, Nujarin, Treeratanapiboon, Lertyot, Kunwittaya, Sarun, Prachayasittikul, Supaluk, Ruchirawat, Somsak, Prachayasittikul, Virapong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834669/
https://www.ncbi.nlm.nih.gov/pubmed/27103894
http://dx.doi.org/10.17179/excli2016-101
Descripción
Sumario:8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and antimicrobial agents. Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities. Moreover, Cu complexes 2 (8AQ-Cu-5Iu) and 5 (8AQ-Cu-5Nu) exerted antimicrobial activities against Gram-negative bacteria including P. shigelloides and S. dysenteriae. The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novel antimalarial and antibacterial agents.

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