Antimalarial and antimicrobial activities of 8-Aminoquinoline-Uracils metal complexes

8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and antimicrobial agents. Interestingly, all of the...

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Autores principales: Phopin, Kamonrat, Sinthupoom, Nujarin, Treeratanapiboon, Lertyot, Kunwittaya, Sarun, Prachayasittikul, Supaluk, Ruchirawat, Somsak, Prachayasittikul, Virapong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834669/
https://www.ncbi.nlm.nih.gov/pubmed/27103894
http://dx.doi.org/10.17179/excli2016-101
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author Phopin, Kamonrat
Sinthupoom, Nujarin
Treeratanapiboon, Lertyot
Kunwittaya, Sarun
Prachayasittikul, Supaluk
Ruchirawat, Somsak
Prachayasittikul, Virapong
author_facet Phopin, Kamonrat
Sinthupoom, Nujarin
Treeratanapiboon, Lertyot
Kunwittaya, Sarun
Prachayasittikul, Supaluk
Ruchirawat, Somsak
Prachayasittikul, Virapong
author_sort Phopin, Kamonrat
collection PubMed
description 8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and antimicrobial agents. Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities. Moreover, Cu complexes 2 (8AQ-Cu-5Iu) and 5 (8AQ-Cu-5Nu) exerted antimicrobial activities against Gram-negative bacteria including P. shigelloides and S. dysenteriae. The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novel antimalarial and antibacterial agents.
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spelling pubmed-48346692016-04-21 Antimalarial and antimicrobial activities of 8-Aminoquinoline-Uracils metal complexes Phopin, Kamonrat Sinthupoom, Nujarin Treeratanapiboon, Lertyot Kunwittaya, Sarun Prachayasittikul, Supaluk Ruchirawat, Somsak Prachayasittikul, Virapong EXCLI J Original Article 8-Aminoquinoline (8AQ) derivatives have been reported to have antimalarial, anticancer, and antioxidant activities. This study investigated the potency of 8AQ-5-substituted (iodo and nitro) uracils metal (Mn, Cu, Ni) complexes (1-6) as antimalarial and antimicrobial agents. Interestingly, all of these metal complexes (1-6) showed fair antimalarial activities. Moreover, Cu complexes 2 (8AQ-Cu-5Iu) and 5 (8AQ-Cu-5Nu) exerted antimicrobial activities against Gram-negative bacteria including P. shigelloides and S. dysenteriae. The results reveal application of 8AQ and its metal complexes as potential compounds to be further developed as novel antimalarial and antibacterial agents. Leibniz Research Centre for Working Environment and Human Factors 2016-02-18 /pmc/articles/PMC4834669/ /pubmed/27103894 http://dx.doi.org/10.17179/excli2016-101 Text en Copyright © 2016 Phopin et al. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/) You are free to copy, distribute and transmit the work, provided the original author and source are credited.
spellingShingle Original Article
Phopin, Kamonrat
Sinthupoom, Nujarin
Treeratanapiboon, Lertyot
Kunwittaya, Sarun
Prachayasittikul, Supaluk
Ruchirawat, Somsak
Prachayasittikul, Virapong
Antimalarial and antimicrobial activities of 8-Aminoquinoline-Uracils metal complexes
title Antimalarial and antimicrobial activities of 8-Aminoquinoline-Uracils metal complexes
title_full Antimalarial and antimicrobial activities of 8-Aminoquinoline-Uracils metal complexes
title_fullStr Antimalarial and antimicrobial activities of 8-Aminoquinoline-Uracils metal complexes
title_full_unstemmed Antimalarial and antimicrobial activities of 8-Aminoquinoline-Uracils metal complexes
title_short Antimalarial and antimicrobial activities of 8-Aminoquinoline-Uracils metal complexes
title_sort antimalarial and antimicrobial activities of 8-aminoquinoline-uracils metal complexes
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834669/
https://www.ncbi.nlm.nih.gov/pubmed/27103894
http://dx.doi.org/10.17179/excli2016-101
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