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Role of Hematocrit Concentration on Successful Extubation in Critically Ill Patients in the Intensive Care Units

BACKGROUND: Hematocrit (Hct) is an important parameter for optimal oxygenation during discontinuation from ventilator, but there is no consensus about its concentration and effectiveness on successful extubation. OBJECTIVES: The current study aimed to determine the role of Hct concentration on extub...

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Autores principales: Beigmohammadi, Mohammad Taghi, Hussain Khan, Zahid, Samadi, Shahram, Mahmoodpoor, Ata, Fotouhi, Akbar, Rahimiforoushani, Abbas, Asadi Gharabaghi, Mehrnaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Kowsar 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834742/
https://www.ncbi.nlm.nih.gov/pubmed/27110535
http://dx.doi.org/10.5812/aapm.32904
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author Beigmohammadi, Mohammad Taghi
Hussain Khan, Zahid
Samadi, Shahram
Mahmoodpoor, Ata
Fotouhi, Akbar
Rahimiforoushani, Abbas
Asadi Gharabaghi, Mehrnaz
author_facet Beigmohammadi, Mohammad Taghi
Hussain Khan, Zahid
Samadi, Shahram
Mahmoodpoor, Ata
Fotouhi, Akbar
Rahimiforoushani, Abbas
Asadi Gharabaghi, Mehrnaz
author_sort Beigmohammadi, Mohammad Taghi
collection PubMed
description BACKGROUND: Hematocrit (Hct) is an important parameter for optimal oxygenation during discontinuation from ventilator, but there is no consensus about its concentration and effectiveness on successful extubation. OBJECTIVES: The current study aimed to determine the role of Hct concentration on extubation failure in critically ill patients. PATIENTS AND METHODS: The current prospective cohort study investigated the effect of age, gender and Hct level on successful extubation of 163 mechanically ventilated patients in Imam Khomeini hospital intensive care units (ICUs), Tehran, Iran. Following successful weaning process, the patients were classified into two groups on the basis of Hct level; 62 with an Hct level of 21% - 27% and the other 101 patients with Hct levels above 27%. The data were analyzed by chi-square test and multiple logistic regressions. A probability value of less than 0.05 was considered significant. RESULTS: There was no significant association between the level of Hct concentration and extubation failure (8.9% vs. 9.2%, P = 0.507). Gender and age were significantly associated with extubation failure (OR = 9.1, P = 0.034, OR = 12.5, P = 0.014, respectively). Although the differences between, before and after extubation of PaO(2) and P/F ratio, were of significant values between the two different groups of Hct (P = 0.001, P = 0.004 respectively), they had no effect on the failure of extubation (P= 0.259, P = 0.403, respectively). CONCLUSIONS: Although some studies showed association between anemia and extubation failure, the current study could not confirm it. The study showed that males, regardless of the Hct level, had a better extubation success rate than those of females.
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spelling pubmed-48347422016-04-22 Role of Hematocrit Concentration on Successful Extubation in Critically Ill Patients in the Intensive Care Units Beigmohammadi, Mohammad Taghi Hussain Khan, Zahid Samadi, Shahram Mahmoodpoor, Ata Fotouhi, Akbar Rahimiforoushani, Abbas Asadi Gharabaghi, Mehrnaz Anesth Pain Med Research Article BACKGROUND: Hematocrit (Hct) is an important parameter for optimal oxygenation during discontinuation from ventilator, but there is no consensus about its concentration and effectiveness on successful extubation. OBJECTIVES: The current study aimed to determine the role of Hct concentration on extubation failure in critically ill patients. PATIENTS AND METHODS: The current prospective cohort study investigated the effect of age, gender and Hct level on successful extubation of 163 mechanically ventilated patients in Imam Khomeini hospital intensive care units (ICUs), Tehran, Iran. Following successful weaning process, the patients were classified into two groups on the basis of Hct level; 62 with an Hct level of 21% - 27% and the other 101 patients with Hct levels above 27%. The data were analyzed by chi-square test and multiple logistic regressions. A probability value of less than 0.05 was considered significant. RESULTS: There was no significant association between the level of Hct concentration and extubation failure (8.9% vs. 9.2%, P = 0.507). Gender and age were significantly associated with extubation failure (OR = 9.1, P = 0.034, OR = 12.5, P = 0.014, respectively). Although the differences between, before and after extubation of PaO(2) and P/F ratio, were of significant values between the two different groups of Hct (P = 0.001, P = 0.004 respectively), they had no effect on the failure of extubation (P= 0.259, P = 0.403, respectively). CONCLUSIONS: Although some studies showed association between anemia and extubation failure, the current study could not confirm it. The study showed that males, regardless of the Hct level, had a better extubation success rate than those of females. Kowsar 2016-01-16 /pmc/articles/PMC4834742/ /pubmed/27110535 http://dx.doi.org/10.5812/aapm.32904 Text en Copyright © 2016, Iranian Society of Regional Anesthesia and Pain Medicine (ISRAPM). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.
spellingShingle Research Article
Beigmohammadi, Mohammad Taghi
Hussain Khan, Zahid
Samadi, Shahram
Mahmoodpoor, Ata
Fotouhi, Akbar
Rahimiforoushani, Abbas
Asadi Gharabaghi, Mehrnaz
Role of Hematocrit Concentration on Successful Extubation in Critically Ill Patients in the Intensive Care Units
title Role of Hematocrit Concentration on Successful Extubation in Critically Ill Patients in the Intensive Care Units
title_full Role of Hematocrit Concentration on Successful Extubation in Critically Ill Patients in the Intensive Care Units
title_fullStr Role of Hematocrit Concentration on Successful Extubation in Critically Ill Patients in the Intensive Care Units
title_full_unstemmed Role of Hematocrit Concentration on Successful Extubation in Critically Ill Patients in the Intensive Care Units
title_short Role of Hematocrit Concentration on Successful Extubation in Critically Ill Patients in the Intensive Care Units
title_sort role of hematocrit concentration on successful extubation in critically ill patients in the intensive care units
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834742/
https://www.ncbi.nlm.nih.gov/pubmed/27110535
http://dx.doi.org/10.5812/aapm.32904
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