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Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation
The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ubiquity Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834752/ https://www.ncbi.nlm.nih.gov/pubmed/27096005 http://dx.doi.org/10.5334/1750-2187-11-1 |
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author | Bertalovitz, Alexander C. Pau, Milly S. Gao, Shujuan Malbon, Craig C. Wang, Hsien-yu |
author_facet | Bertalovitz, Alexander C. Pau, Milly S. Gao, Shujuan Malbon, Craig C. Wang, Hsien-yu |
author_sort | Bertalovitz, Alexander C. |
collection | PubMed |
description | The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin. |
format | Online Article Text |
id | pubmed-4834752 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Ubiquity Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-48347522016-04-19 Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation Bertalovitz, Alexander C. Pau, Milly S. Gao, Shujuan Malbon, Craig C. Wang, Hsien-yu J Mol Signal Short Report The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin. Ubiquity Press 2016-02-05 /pmc/articles/PMC4834752/ /pubmed/27096005 http://dx.doi.org/10.5334/1750-2187-11-1 Text en Copyright: © 2016 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Short Report Bertalovitz, Alexander C. Pau, Milly S. Gao, Shujuan Malbon, Craig C. Wang, Hsien-yu Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation |
title | Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation |
title_full | Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation |
title_fullStr | Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation |
title_full_unstemmed | Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation |
title_short | Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation |
title_sort | frizzled-4 c-terminus distal to ktxxxw motif is essential for normal dishevelled recruitment and norrin-stimulated activation of lef/tcf-dependent transcriptional activation |
topic | Short Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834752/ https://www.ncbi.nlm.nih.gov/pubmed/27096005 http://dx.doi.org/10.5334/1750-2187-11-1 |
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