Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation

The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal...

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Autores principales: Bertalovitz, Alexander C., Pau, Milly S., Gao, Shujuan, Malbon, Craig C., Wang, Hsien-yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ubiquity Press 2016
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834752/
https://www.ncbi.nlm.nih.gov/pubmed/27096005
http://dx.doi.org/10.5334/1750-2187-11-1
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author Bertalovitz, Alexander C.
Pau, Milly S.
Gao, Shujuan
Malbon, Craig C.
Wang, Hsien-yu
author_facet Bertalovitz, Alexander C.
Pau, Milly S.
Gao, Shujuan
Malbon, Craig C.
Wang, Hsien-yu
author_sort Bertalovitz, Alexander C.
collection PubMed
description The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin.
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spelling pubmed-48347522016-04-19 Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation Bertalovitz, Alexander C. Pau, Milly S. Gao, Shujuan Malbon, Craig C. Wang, Hsien-yu J Mol Signal Short Report The carboxy (C)-termini of G protein coupled receptors (GPCR) dictate essential functions. The KTXXXW motif C-terminus of Frizzleds (FZD) has been implicated in recruitment of Dishevelled (DVL). Through study of FZD4 and its associated ligand Norrin, we report that a minimum of three residues distal to the KTXXXW motif in the C-terminal tail of Frizzled-4 are essential for DVL recruitment and robust Lef/Tcf-dependent transcriptional activation in response to Norrin. Ubiquity Press 2016-02-05 /pmc/articles/PMC4834752/ /pubmed/27096005 http://dx.doi.org/10.5334/1750-2187-11-1 Text en Copyright: © 2016 The Author(s) http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. See http://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Report
Bertalovitz, Alexander C.
Pau, Milly S.
Gao, Shujuan
Malbon, Craig C.
Wang, Hsien-yu
Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation
title Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation
title_full Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation
title_fullStr Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation
title_full_unstemmed Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation
title_short Frizzled-4 C-terminus Distal to KTXXXW Motif is Essential for Normal Dishevelled Recruitment and Norrin-stimulated Activation of Lef/Tcf-dependent Transcriptional Activation
title_sort frizzled-4 c-terminus distal to ktxxxw motif is essential for normal dishevelled recruitment and norrin-stimulated activation of lef/tcf-dependent transcriptional activation
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834752/
https://www.ncbi.nlm.nih.gov/pubmed/27096005
http://dx.doi.org/10.5334/1750-2187-11-1
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