Trans-1,3-diphenyl-2,3-epoxypropan-1-one, a chalcone derivative, induces apoptosis via ROS-mediated down-regulation of Bcl-xL in human leukemia HL-60 cells

The anticancer effects of trans-1,3-diphenyl-2,3-epoxypropan-1-one (DPEP), a chalcone derivative, were investigated in human leukemia HL-60 cells. Treatment of HL-60 cells with various concentration of DPEP resulted in a sequence of events characteristic of apoptosis, including loss of cell viabilit...

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Detalles Bibliográficos
Autores principales: Ko, Eun-Yi, Lee, Seung-Hong, Ko, Ji-Yeon, Moon, Jeong Yong, Yoon, Weon-Jong, Ahn, Ginnae, Roh, Seong Woon, Cho, Kichul, Jeon, You-Jin, Kim, Daekyung, Kim, Kil-Nam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834817/
https://www.ncbi.nlm.nih.gov/pubmed/27103891
http://dx.doi.org/10.17179/excli2015-373

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