Successful treatment of osteonecrosis-induced fractured mandible with teriparatide therapy: A case report

INTRODUCTION: The management of medication-related osteonecrosis of the jaw (MRONJ) is controversial. To date, there is no established treatment for cases of advanced stage 3 MRONJ osteoporosis in elderly patients. PRESENTATION: An 87-year-old osteoporotic woman with osteonecrosis-induced left mandi...

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Autores principales: Yao, Mayumi, Shimo, Tsuyoshi, Ono, Yuko, Obata, Kyoichi, Yoshioka, Norie, Sasaki, Akira
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834826/
https://www.ncbi.nlm.nih.gov/pubmed/26947555
http://dx.doi.org/10.1016/j.ijscr.2016.02.028
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author Yao, Mayumi
Shimo, Tsuyoshi
Ono, Yuko
Obata, Kyoichi
Yoshioka, Norie
Sasaki, Akira
author_facet Yao, Mayumi
Shimo, Tsuyoshi
Ono, Yuko
Obata, Kyoichi
Yoshioka, Norie
Sasaki, Akira
author_sort Yao, Mayumi
collection PubMed
description INTRODUCTION: The management of medication-related osteonecrosis of the jaw (MRONJ) is controversial. To date, there is no established treatment for cases of advanced stage 3 MRONJ osteoporosis in elderly patients. PRESENTATION: An 87-year-old osteoporotic woman with osteonecrosis-induced left mandible fracture related to minodronate therapy was referred to us for treatment. She had a vertebral compression fracture concurrently and had started subcutaneous injection of teriparatide. After 18 months of treatment with teriparatide the pathological mandible fracture was healed and functional recovery of the occlusion was obtained by complete dentures. DISCUSSION: Teriparatide may have a powerful anabolic effect on bone, and promote bone regeneration against pathologic mandible fracture induced by MRONJ. CONCLUSION: Based upon these findings, teriparatide might be beneficial for advanced stage 3 MRONJ osteoporosis in elderly patients.
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spelling pubmed-48348262016-04-29 Successful treatment of osteonecrosis-induced fractured mandible with teriparatide therapy: A case report Yao, Mayumi Shimo, Tsuyoshi Ono, Yuko Obata, Kyoichi Yoshioka, Norie Sasaki, Akira Int J Surg Case Rep Case Report INTRODUCTION: The management of medication-related osteonecrosis of the jaw (MRONJ) is controversial. To date, there is no established treatment for cases of advanced stage 3 MRONJ osteoporosis in elderly patients. PRESENTATION: An 87-year-old osteoporotic woman with osteonecrosis-induced left mandible fracture related to minodronate therapy was referred to us for treatment. She had a vertebral compression fracture concurrently and had started subcutaneous injection of teriparatide. After 18 months of treatment with teriparatide the pathological mandible fracture was healed and functional recovery of the occlusion was obtained by complete dentures. DISCUSSION: Teriparatide may have a powerful anabolic effect on bone, and promote bone regeneration against pathologic mandible fracture induced by MRONJ. CONCLUSION: Based upon these findings, teriparatide might be beneficial for advanced stage 3 MRONJ osteoporosis in elderly patients. Elsevier 2016-03-03 /pmc/articles/PMC4834826/ /pubmed/26947555 http://dx.doi.org/10.1016/j.ijscr.2016.02.028 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Yao, Mayumi
Shimo, Tsuyoshi
Ono, Yuko
Obata, Kyoichi
Yoshioka, Norie
Sasaki, Akira
Successful treatment of osteonecrosis-induced fractured mandible with teriparatide therapy: A case report
title Successful treatment of osteonecrosis-induced fractured mandible with teriparatide therapy: A case report
title_full Successful treatment of osteonecrosis-induced fractured mandible with teriparatide therapy: A case report
title_fullStr Successful treatment of osteonecrosis-induced fractured mandible with teriparatide therapy: A case report
title_full_unstemmed Successful treatment of osteonecrosis-induced fractured mandible with teriparatide therapy: A case report
title_short Successful treatment of osteonecrosis-induced fractured mandible with teriparatide therapy: A case report
title_sort successful treatment of osteonecrosis-induced fractured mandible with teriparatide therapy: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834826/
https://www.ncbi.nlm.nih.gov/pubmed/26947555
http://dx.doi.org/10.1016/j.ijscr.2016.02.028
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