Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity

Emerging single-cell epigenomic methods are being developed with the exciting potential to transform our knowledge of gene regulation. Here we review available techniques and future possibilities, arguing that the full potential of single-cell epigenetic studies will be realized through parallel pro...

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Detalles Bibliográficos
Autores principales: Clark, Stephen J., Lee, Heather J., Smallwood, Sébastien A., Kelsey, Gavin, Reik, Wolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834828/
https://www.ncbi.nlm.nih.gov/pubmed/27091476
http://dx.doi.org/10.1186/s13059-016-0944-x
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author Clark, Stephen J.
Lee, Heather J.
Smallwood, Sébastien A.
Kelsey, Gavin
Reik, Wolf
author_facet Clark, Stephen J.
Lee, Heather J.
Smallwood, Sébastien A.
Kelsey, Gavin
Reik, Wolf
author_sort Clark, Stephen J.
collection PubMed
description Emerging single-cell epigenomic methods are being developed with the exciting potential to transform our knowledge of gene regulation. Here we review available techniques and future possibilities, arguing that the full potential of single-cell epigenetic studies will be realized through parallel profiling of genomic, transcriptional, and epigenetic information.
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spelling pubmed-48348282016-04-19 Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity Clark, Stephen J. Lee, Heather J. Smallwood, Sébastien A. Kelsey, Gavin Reik, Wolf Genome Biol Opinion Emerging single-cell epigenomic methods are being developed with the exciting potential to transform our knowledge of gene regulation. Here we review available techniques and future possibilities, arguing that the full potential of single-cell epigenetic studies will be realized through parallel profiling of genomic, transcriptional, and epigenetic information. BioMed Central 2016-04-18 /pmc/articles/PMC4834828/ /pubmed/27091476 http://dx.doi.org/10.1186/s13059-016-0944-x Text en © Clark et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Opinion
Clark, Stephen J.
Lee, Heather J.
Smallwood, Sébastien A.
Kelsey, Gavin
Reik, Wolf
Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity
title Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity
title_full Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity
title_fullStr Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity
title_full_unstemmed Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity
title_short Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity
title_sort single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834828/
https://www.ncbi.nlm.nih.gov/pubmed/27091476
http://dx.doi.org/10.1186/s13059-016-0944-x
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