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Brain white matter integrity in heroin addicts during methadone maintenance treatment is related to relapse propensity

INTRODUCTION: Cognitive deficits caused by heroin‐induced white matter (WM) impairments hinder addicts' engagement in and benefit from treatment. The predictive value of WM integrity in heroin addicts during methadone maintenance treatment (MMT) for future relapse is unclear. METHODS: Forty‐eig...

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Autores principales: Li, Wei, Zhu, Jia, Li, Qiang, Ye, Jianjun, Chen, Jiajie, Liu, Jierong, Li, Zhe, Li, Yongbin, Yan, Xuejiao, Wang, Yarong, Wang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834937/
https://www.ncbi.nlm.nih.gov/pubmed/27110449
http://dx.doi.org/10.1002/brb3.436
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author Li, Wei
Zhu, Jia
Li, Qiang
Ye, Jianjun
Chen, Jiajie
Liu, Jierong
Li, Zhe
Li, Yongbin
Yan, Xuejiao
Wang, Yarong
Wang, Wei
author_facet Li, Wei
Zhu, Jia
Li, Qiang
Ye, Jianjun
Chen, Jiajie
Liu, Jierong
Li, Zhe
Li, Yongbin
Yan, Xuejiao
Wang, Yarong
Wang, Wei
author_sort Li, Wei
collection PubMed
description INTRODUCTION: Cognitive deficits caused by heroin‐induced white matter (WM) impairments hinder addicts' engagement in and benefit from treatment. The predictive value of WM integrity in heroin addicts during methadone maintenance treatment (MMT) for future relapse is unclear. METHODS: Forty‐eight MMT patients were given baseline diffusion tensor imaging scans and divided into heroin relapsers (HR, 25 cases) and abstainers (HA, 23 cases) according to the results of 6‐month follow‐up. Intergroup comparisons were performed for fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). The correlation between diffusion tensor imaging indices and the degree of heroin relapse was analyzed. RESULTS: Compared with HA group, HR group had reduced FA in the right retrolenticular part, left anterior and posterior limb of internal capsule, bilateral anterior corona radiata, and right external capsule. Three out of the six regions showed increased RD, with no changes in AD. The FA and AD values in the left posterior limb of internal capsule correlated negatively with the heroin‐positive urinalysis rate within follow‐up. CONCLUSIONS: Lower WM integrity in MMT patients may add to neurobiological factors associated with relapse to heroin use. Strategies for improving WM integrity provide a new perspective to prevent future relapse to heroin abuse.
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spelling pubmed-48349372016-04-22 Brain white matter integrity in heroin addicts during methadone maintenance treatment is related to relapse propensity Li, Wei Zhu, Jia Li, Qiang Ye, Jianjun Chen, Jiajie Liu, Jierong Li, Zhe Li, Yongbin Yan, Xuejiao Wang, Yarong Wang, Wei Brain Behav Original Research INTRODUCTION: Cognitive deficits caused by heroin‐induced white matter (WM) impairments hinder addicts' engagement in and benefit from treatment. The predictive value of WM integrity in heroin addicts during methadone maintenance treatment (MMT) for future relapse is unclear. METHODS: Forty‐eight MMT patients were given baseline diffusion tensor imaging scans and divided into heroin relapsers (HR, 25 cases) and abstainers (HA, 23 cases) according to the results of 6‐month follow‐up. Intergroup comparisons were performed for fractional anisotropy (FA), radial diffusivity (RD), and axial diffusivity (AD). The correlation between diffusion tensor imaging indices and the degree of heroin relapse was analyzed. RESULTS: Compared with HA group, HR group had reduced FA in the right retrolenticular part, left anterior and posterior limb of internal capsule, bilateral anterior corona radiata, and right external capsule. Three out of the six regions showed increased RD, with no changes in AD. The FA and AD values in the left posterior limb of internal capsule correlated negatively with the heroin‐positive urinalysis rate within follow‐up. CONCLUSIONS: Lower WM integrity in MMT patients may add to neurobiological factors associated with relapse to heroin use. Strategies for improving WM integrity provide a new perspective to prevent future relapse to heroin abuse. John Wiley and Sons Inc. 2016-01-24 /pmc/articles/PMC4834937/ /pubmed/27110449 http://dx.doi.org/10.1002/brb3.436 Text en © 2016 The Authors. Brain and Behavior published by Wiley Periodicals, Inc. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Li, Wei
Zhu, Jia
Li, Qiang
Ye, Jianjun
Chen, Jiajie
Liu, Jierong
Li, Zhe
Li, Yongbin
Yan, Xuejiao
Wang, Yarong
Wang, Wei
Brain white matter integrity in heroin addicts during methadone maintenance treatment is related to relapse propensity
title Brain white matter integrity in heroin addicts during methadone maintenance treatment is related to relapse propensity
title_full Brain white matter integrity in heroin addicts during methadone maintenance treatment is related to relapse propensity
title_fullStr Brain white matter integrity in heroin addicts during methadone maintenance treatment is related to relapse propensity
title_full_unstemmed Brain white matter integrity in heroin addicts during methadone maintenance treatment is related to relapse propensity
title_short Brain white matter integrity in heroin addicts during methadone maintenance treatment is related to relapse propensity
title_sort brain white matter integrity in heroin addicts during methadone maintenance treatment is related to relapse propensity
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4834937/
https://www.ncbi.nlm.nih.gov/pubmed/27110449
http://dx.doi.org/10.1002/brb3.436
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