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Interleukin-25 Mediated Induction of Angiogenin-4 Is Interleukin-13 Dependent
The intestinal surface is directly exposed to both commensal microorganisms as well as pathogens with a single layer of epithelium separating luminal microorganisms from internal tissues. Antimicrobial peptides play a crucial role in allowing epithelial cells to contain in the lumen beneficial and p...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835063/ https://www.ncbi.nlm.nih.gov/pubmed/27089535 http://dx.doi.org/10.1371/journal.pone.0153572 |
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author | Noor, Zannatun Burgess, Stacey L. Watanabe, Koji Petri, William A. |
author_facet | Noor, Zannatun Burgess, Stacey L. Watanabe, Koji Petri, William A. |
author_sort | Noor, Zannatun |
collection | PubMed |
description | The intestinal surface is directly exposed to both commensal microorganisms as well as pathogens with a single layer of epithelium separating luminal microorganisms from internal tissues. Antimicrobial peptides play a crucial role in allowing epithelial cells to contain in the lumen beneficial and pathogenic microorganisms. The commensal dependent, epithelial produced, Th2 cytokine IL-25 can induce IL-13 and potentially the antimicrobial peptide angiogenin-4. Here we show that IL-13 downstream of IL-25 is required to induce angiogenin-4. IL-25 mediated induction of angiogenin-4 is furthermore not dependent on IL-22 or IL-17. |
format | Online Article Text |
id | pubmed-4835063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-48350632016-04-29 Interleukin-25 Mediated Induction of Angiogenin-4 Is Interleukin-13 Dependent Noor, Zannatun Burgess, Stacey L. Watanabe, Koji Petri, William A. PLoS One Research Article The intestinal surface is directly exposed to both commensal microorganisms as well as pathogens with a single layer of epithelium separating luminal microorganisms from internal tissues. Antimicrobial peptides play a crucial role in allowing epithelial cells to contain in the lumen beneficial and pathogenic microorganisms. The commensal dependent, epithelial produced, Th2 cytokine IL-25 can induce IL-13 and potentially the antimicrobial peptide angiogenin-4. Here we show that IL-13 downstream of IL-25 is required to induce angiogenin-4. IL-25 mediated induction of angiogenin-4 is furthermore not dependent on IL-22 or IL-17. Public Library of Science 2016-04-18 /pmc/articles/PMC4835063/ /pubmed/27089535 http://dx.doi.org/10.1371/journal.pone.0153572 Text en © 2016 Noor et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Noor, Zannatun Burgess, Stacey L. Watanabe, Koji Petri, William A. Interleukin-25 Mediated Induction of Angiogenin-4 Is Interleukin-13 Dependent |
title | Interleukin-25 Mediated Induction of Angiogenin-4 Is Interleukin-13 Dependent |
title_full | Interleukin-25 Mediated Induction of Angiogenin-4 Is Interleukin-13 Dependent |
title_fullStr | Interleukin-25 Mediated Induction of Angiogenin-4 Is Interleukin-13 Dependent |
title_full_unstemmed | Interleukin-25 Mediated Induction of Angiogenin-4 Is Interleukin-13 Dependent |
title_short | Interleukin-25 Mediated Induction of Angiogenin-4 Is Interleukin-13 Dependent |
title_sort | interleukin-25 mediated induction of angiogenin-4 is interleukin-13 dependent |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835063/ https://www.ncbi.nlm.nih.gov/pubmed/27089535 http://dx.doi.org/10.1371/journal.pone.0153572 |
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