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Interleukin-25 Mediated Induction of Angiogenin-4 Is Interleukin-13 Dependent

The intestinal surface is directly exposed to both commensal microorganisms as well as pathogens with a single layer of epithelium separating luminal microorganisms from internal tissues. Antimicrobial peptides play a crucial role in allowing epithelial cells to contain in the lumen beneficial and p...

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Detalles Bibliográficos
Autores principales: Noor, Zannatun, Burgess, Stacey L., Watanabe, Koji, Petri, William A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835063/
https://www.ncbi.nlm.nih.gov/pubmed/27089535
http://dx.doi.org/10.1371/journal.pone.0153572
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author Noor, Zannatun
Burgess, Stacey L.
Watanabe, Koji
Petri, William A.
author_facet Noor, Zannatun
Burgess, Stacey L.
Watanabe, Koji
Petri, William A.
author_sort Noor, Zannatun
collection PubMed
description The intestinal surface is directly exposed to both commensal microorganisms as well as pathogens with a single layer of epithelium separating luminal microorganisms from internal tissues. Antimicrobial peptides play a crucial role in allowing epithelial cells to contain in the lumen beneficial and pathogenic microorganisms. The commensal dependent, epithelial produced, Th2 cytokine IL-25 can induce IL-13 and potentially the antimicrobial peptide angiogenin-4. Here we show that IL-13 downstream of IL-25 is required to induce angiogenin-4. IL-25 mediated induction of angiogenin-4 is furthermore not dependent on IL-22 or IL-17.
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spelling pubmed-48350632016-04-29 Interleukin-25 Mediated Induction of Angiogenin-4 Is Interleukin-13 Dependent Noor, Zannatun Burgess, Stacey L. Watanabe, Koji Petri, William A. PLoS One Research Article The intestinal surface is directly exposed to both commensal microorganisms as well as pathogens with a single layer of epithelium separating luminal microorganisms from internal tissues. Antimicrobial peptides play a crucial role in allowing epithelial cells to contain in the lumen beneficial and pathogenic microorganisms. The commensal dependent, epithelial produced, Th2 cytokine IL-25 can induce IL-13 and potentially the antimicrobial peptide angiogenin-4. Here we show that IL-13 downstream of IL-25 is required to induce angiogenin-4. IL-25 mediated induction of angiogenin-4 is furthermore not dependent on IL-22 or IL-17. Public Library of Science 2016-04-18 /pmc/articles/PMC4835063/ /pubmed/27089535 http://dx.doi.org/10.1371/journal.pone.0153572 Text en © 2016 Noor et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Noor, Zannatun
Burgess, Stacey L.
Watanabe, Koji
Petri, William A.
Interleukin-25 Mediated Induction of Angiogenin-4 Is Interleukin-13 Dependent
title Interleukin-25 Mediated Induction of Angiogenin-4 Is Interleukin-13 Dependent
title_full Interleukin-25 Mediated Induction of Angiogenin-4 Is Interleukin-13 Dependent
title_fullStr Interleukin-25 Mediated Induction of Angiogenin-4 Is Interleukin-13 Dependent
title_full_unstemmed Interleukin-25 Mediated Induction of Angiogenin-4 Is Interleukin-13 Dependent
title_short Interleukin-25 Mediated Induction of Angiogenin-4 Is Interleukin-13 Dependent
title_sort interleukin-25 mediated induction of angiogenin-4 is interleukin-13 dependent
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835063/
https://www.ncbi.nlm.nih.gov/pubmed/27089535
http://dx.doi.org/10.1371/journal.pone.0153572
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