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Endoscopic Tumor Length Should Be Reincluded in the Esophageal Cancer Staging System: Analyses of 662 Consecutive Patients

Esophageal cancer represents the 6(th) cause of cancer mortality in the World. New treatments led to outcome improvements, but patient selection and prognostic stratification is a critical aspect to gain maximum benefit from therapies. Today, patients are stratified into 9 prognostic groups, accordi...

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Autores principales: Valmasoni, Michele, Pierobon, Elisa Sefora, Ruol, Alberto, De Pasqual, Carlo Alberto, Zanchettin, Gianpietro, Moletta, Lucia, Salvador, Renato, Costantini, Mario, Merigliano, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835067/
https://www.ncbi.nlm.nih.gov/pubmed/27088503
http://dx.doi.org/10.1371/journal.pone.0153068
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author Valmasoni, Michele
Pierobon, Elisa Sefora
Ruol, Alberto
De Pasqual, Carlo Alberto
Zanchettin, Gianpietro
Moletta, Lucia
Salvador, Renato
Costantini, Mario
Merigliano, Stefano
author_facet Valmasoni, Michele
Pierobon, Elisa Sefora
Ruol, Alberto
De Pasqual, Carlo Alberto
Zanchettin, Gianpietro
Moletta, Lucia
Salvador, Renato
Costantini, Mario
Merigliano, Stefano
author_sort Valmasoni, Michele
collection PubMed
description Esophageal cancer represents the 6(th) cause of cancer mortality in the World. New treatments led to outcome improvements, but patient selection and prognostic stratification is a critical aspect to gain maximum benefit from therapies. Today, patients are stratified into 9 prognostic groups, according to a staging system developed by the American Joint Committee on Cancer. Recently, trying to better select patients with curing possibilities several authors are reconsidering tumor length as a valuable prognostic parameter. Specifically, endoscopic tumor length can be easily measured with an esophageal endoscopy and, if its utility in esophageal cancer staging is demonstrated, it may represent a simple method to identify high risk patients and an easy-to-obtain variable in prognostic stratification. In this study we retrospectively analyzed 662 patients treated for esophageal cancer, stratified according to cancer histology and current staging system, to assess the possible role of endoscopic tumor length. We found a significant correlation between endoscopic tumor length, current staging parameters and 5-year survival, proving that endoscopic tumor length may be used as a simple risk stratification tool. Our results suggest a possible indication for preoperative therapy in early stage squamocellular carcinoma patients without lymph nodes involvement, who are currently treated with surgery alone.
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spelling pubmed-48350672016-04-29 Endoscopic Tumor Length Should Be Reincluded in the Esophageal Cancer Staging System: Analyses of 662 Consecutive Patients Valmasoni, Michele Pierobon, Elisa Sefora Ruol, Alberto De Pasqual, Carlo Alberto Zanchettin, Gianpietro Moletta, Lucia Salvador, Renato Costantini, Mario Merigliano, Stefano PLoS One Research Article Esophageal cancer represents the 6(th) cause of cancer mortality in the World. New treatments led to outcome improvements, but patient selection and prognostic stratification is a critical aspect to gain maximum benefit from therapies. Today, patients are stratified into 9 prognostic groups, according to a staging system developed by the American Joint Committee on Cancer. Recently, trying to better select patients with curing possibilities several authors are reconsidering tumor length as a valuable prognostic parameter. Specifically, endoscopic tumor length can be easily measured with an esophageal endoscopy and, if its utility in esophageal cancer staging is demonstrated, it may represent a simple method to identify high risk patients and an easy-to-obtain variable in prognostic stratification. In this study we retrospectively analyzed 662 patients treated for esophageal cancer, stratified according to cancer histology and current staging system, to assess the possible role of endoscopic tumor length. We found a significant correlation between endoscopic tumor length, current staging parameters and 5-year survival, proving that endoscopic tumor length may be used as a simple risk stratification tool. Our results suggest a possible indication for preoperative therapy in early stage squamocellular carcinoma patients without lymph nodes involvement, who are currently treated with surgery alone. Public Library of Science 2016-04-18 /pmc/articles/PMC4835067/ /pubmed/27088503 http://dx.doi.org/10.1371/journal.pone.0153068 Text en © 2016 Valmasoni et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Valmasoni, Michele
Pierobon, Elisa Sefora
Ruol, Alberto
De Pasqual, Carlo Alberto
Zanchettin, Gianpietro
Moletta, Lucia
Salvador, Renato
Costantini, Mario
Merigliano, Stefano
Endoscopic Tumor Length Should Be Reincluded in the Esophageal Cancer Staging System: Analyses of 662 Consecutive Patients
title Endoscopic Tumor Length Should Be Reincluded in the Esophageal Cancer Staging System: Analyses of 662 Consecutive Patients
title_full Endoscopic Tumor Length Should Be Reincluded in the Esophageal Cancer Staging System: Analyses of 662 Consecutive Patients
title_fullStr Endoscopic Tumor Length Should Be Reincluded in the Esophageal Cancer Staging System: Analyses of 662 Consecutive Patients
title_full_unstemmed Endoscopic Tumor Length Should Be Reincluded in the Esophageal Cancer Staging System: Analyses of 662 Consecutive Patients
title_short Endoscopic Tumor Length Should Be Reincluded in the Esophageal Cancer Staging System: Analyses of 662 Consecutive Patients
title_sort endoscopic tumor length should be reincluded in the esophageal cancer staging system: analyses of 662 consecutive patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835067/
https://www.ncbi.nlm.nih.gov/pubmed/27088503
http://dx.doi.org/10.1371/journal.pone.0153068
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