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Fragment-Based Approaches to the Development of Mycobacterium tuberculosis CYP121 Inhibitors

[Image: see text] The essential enzyme CYP121 is a target for drug development against antibiotic resistant strains of Mycobacterium tuberculosis. A triazol-1-yl phenol fragment 1 was identified to bind to CYP121 using a cascade of biophysical assays. Synthetic merging and optimization of 1 produced...

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Detalles Bibliográficos
Autores principales:	Kavanagh, Madeline E., Coyne, Anthony G., McLean, Kirsty J., James, Guy G., Levy, Colin W., Marino, Leonardo B., de Carvalho, Luiz Pedro S., Chan, Daniel S. H., Hudson, Sean A., Surade, Sachin, Leys, David, Munro, Andrew W., Abell, Chris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2016
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835159/ https://www.ncbi.nlm.nih.gov/pubmed/27002486 http://dx.doi.org/10.1021/acs.jmedchem.6b00007

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