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OSU‐03012 and Viagra Treatment Inhibits the Activity of Multiple Chaperone Proteins and Disrupts the Blood–Brain Barrier: Implications for Anti‐Cancer Therapies

We examined the interaction between OSU‐03012 (also called AR‐12) with phosphodiesterase 5 (PDE5) inhibitors to determine the role of the chaperone glucose‐regulated protein (GRP78)/BiP/HSPA5 in the cellular response. Sildenafil (Viagra) interacted in a greater than additive fashion with OSU‐03012 t...

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Detalles Bibliográficos
Autores principales:	Booth, Laurence, Roberts, Jane L., Tavallai, Mehrad, Nourbakhsh, Aida, Chuckalovcak, John, Carter, Jori, Poklepovic, Andrew, Dent, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	Original Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835175/ https://www.ncbi.nlm.nih.gov/pubmed/25736380 http://dx.doi.org/10.1002/jcp.24977

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