A Case of Disseminated Multidrug-Resistant Tuberculosis involving the Brain

We report a case of a 23-year-old female immigrant from China who was diagnosed with multidrug-resistant tuberculosis affecting her lung and brain, resistant to the standard first-line therapeutics and streptomycin. She was treated with prothionamide, moxifloxacin, cycloserine, and kanamycin. Howeve...

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Autores principales: Jung, Eun Kyo, Chang, Ji Young, Lee, Yoon Pyo, Chung, Min Kyung, Seo, Eui Kyo, Koo, Hea Soo, Choi, Hee Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Infectious Diseases and Korean Society for Chemotherapy 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835434/
https://www.ncbi.nlm.nih.gov/pubmed/27104015
http://dx.doi.org/10.3947/ic.2016.48.1.41
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author Jung, Eun Kyo
Chang, Ji Young
Lee, Yoon Pyo
Chung, Min Kyung
Seo, Eui Kyo
Koo, Hea Soo
Choi, Hee Jung
author_facet Jung, Eun Kyo
Chang, Ji Young
Lee, Yoon Pyo
Chung, Min Kyung
Seo, Eui Kyo
Koo, Hea Soo
Choi, Hee Jung
author_sort Jung, Eun Kyo
collection PubMed
description We report a case of a 23-year-old female immigrant from China who was diagnosed with multidrug-resistant tuberculosis affecting her lung and brain, resistant to the standard first-line therapeutics and streptomycin. She was treated with prothionamide, moxifloxacin, cycloserine, and kanamycin. However, her headache and brain lesion worsened. After the brain biopsy, the patient was confirmed with intracranial tuberculoma. Linezolid was added to intensify the treatment regimen, and steroid was added for the possibility of paradoxical response. Kanamycin was discontinued 6 months after initiation of the treatment; she was treated for 18 months with susceptible drugs and completely recovered. To our knowledge, this case is the first multidrug-resistant tuberculosis that disseminated to the brain in Korea.
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spelling pubmed-48354342016-04-21 A Case of Disseminated Multidrug-Resistant Tuberculosis involving the Brain Jung, Eun Kyo Chang, Ji Young Lee, Yoon Pyo Chung, Min Kyung Seo, Eui Kyo Koo, Hea Soo Choi, Hee Jung Infect Chemother Case Report We report a case of a 23-year-old female immigrant from China who was diagnosed with multidrug-resistant tuberculosis affecting her lung and brain, resistant to the standard first-line therapeutics and streptomycin. She was treated with prothionamide, moxifloxacin, cycloserine, and kanamycin. However, her headache and brain lesion worsened. After the brain biopsy, the patient was confirmed with intracranial tuberculoma. Linezolid was added to intensify the treatment regimen, and steroid was added for the possibility of paradoxical response. Kanamycin was discontinued 6 months after initiation of the treatment; she was treated for 18 months with susceptible drugs and completely recovered. To our knowledge, this case is the first multidrug-resistant tuberculosis that disseminated to the brain in Korea. The Korean Society of Infectious Diseases and Korean Society for Chemotherapy 2016-03 2016-03-31 /pmc/articles/PMC4835434/ /pubmed/27104015 http://dx.doi.org/10.3947/ic.2016.48.1.41 Text en Copyright © 2016 by The Korean Society of Infectious Diseases and Korean Society for Chemotherapy http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Jung, Eun Kyo
Chang, Ji Young
Lee, Yoon Pyo
Chung, Min Kyung
Seo, Eui Kyo
Koo, Hea Soo
Choi, Hee Jung
A Case of Disseminated Multidrug-Resistant Tuberculosis involving the Brain
title A Case of Disseminated Multidrug-Resistant Tuberculosis involving the Brain
title_full A Case of Disseminated Multidrug-Resistant Tuberculosis involving the Brain
title_fullStr A Case of Disseminated Multidrug-Resistant Tuberculosis involving the Brain
title_full_unstemmed A Case of Disseminated Multidrug-Resistant Tuberculosis involving the Brain
title_short A Case of Disseminated Multidrug-Resistant Tuberculosis involving the Brain
title_sort case of disseminated multidrug-resistant tuberculosis involving the brain
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835434/
https://www.ncbi.nlm.nih.gov/pubmed/27104015
http://dx.doi.org/10.3947/ic.2016.48.1.41
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