An Integrative Data Science Pipeline to Identify Novel Drug Interactions that Prolong the QT Interval

INTRODUCTION: Drug-induced prolongation of the QT interval on the electrocardiogram (long QT syndrome, LQTS) can lead to a potentially fatal ventricular arrhythmia known as torsades de pointes (TdP). Over 40 drugs with both cardiac and non-cardiac indications are associated with increased risk of Td...

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Detalles Bibliográficos
Autores principales: Lorberbaum, Tal, Sampson, Kevin J., Woosley, Raymond L., Kass, Robert S., Tatonetti, Nicholas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2016
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835515/
https://www.ncbi.nlm.nih.gov/pubmed/26860921
http://dx.doi.org/10.1007/s40264-016-0393-1

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