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Harnessing publicly available genetic data to prioritize lipid modifying therapeutic targets for prevention of coronary heart disease based on dysglycemic risk
Therapeutic interventions that lower LDL-cholesterol effectively reduce the risk of coronary artery disease (CAD). However, statins, the most widely prescribed LDL-cholesterol lowering drugs, increase diabetes risk. We used genome-wide association study (GWAS) data in the public domain to investigat...
Autores principales: | Tragante, Vinicius, Asselbergs, Folkert W., Swerdlow, Daniel I., Palmer, Tom M., Moore, Jason H., de Bakker, Paul I. W., Keating, Brendan J., Holmes, Michael V. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835528/ https://www.ncbi.nlm.nih.gov/pubmed/26946290 http://dx.doi.org/10.1007/s00439-016-1647-9 |
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