Angiopoietin-2-induced blood–brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling

The homeostasis of the central nervous system is maintained by the blood–brain barrier (BBB). Angiopoietins (Ang-1/Ang-2) act as antagonizing molecules to regulate angiogenesis, vascular stability, vascular permeability and lymphatic integrity. However, the precise role of angiopoietin/Tie2 signalin...

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Detalles Bibliográficos
Autores principales: Gurnik, Stefanie, Devraj, Kavi, Macas, Jadranka, Yamaji, Maiko, Starke, Julia, Scholz, Alexander, Sommer, Kathleen, Di Tacchio, Mariangela, Vutukuri, Rajkumar, Beck, Heike, Mittelbronn, Michel, Foerch, Christian, Pfeilschifter, Waltraud, Liebner, Stefan, Peters, Kevin G., Plate, Karl H., Reiss, Yvonne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2016
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835530/
https://www.ncbi.nlm.nih.gov/pubmed/26932603
http://dx.doi.org/10.1007/s00401-016-1551-3

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