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The Effects of Alcohol on Visual Evoked Potential and Multifocal Electroretinography

The aim of this study was to investigate the acute effects of ethanol administration on pattern-reversal visual evoked potential (VEP) and multifocal electroretinography (mfERG). Fifteen healthy subjects with no ocular or general disease were recruited. VEP (0.25° pattern sizes) and mfERG with 19 el...

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Autores principales: Kim, Jee Taek, Yun, Cheol Min, Kim, Seong-Woo, Oh, Jaeryung, Huh, Kuhl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835606/
https://www.ncbi.nlm.nih.gov/pubmed/27134502
http://dx.doi.org/10.3346/jkms.2016.31.5.783
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author Kim, Jee Taek
Yun, Cheol Min
Kim, Seong-Woo
Oh, Jaeryung
Huh, Kuhl
author_facet Kim, Jee Taek
Yun, Cheol Min
Kim, Seong-Woo
Oh, Jaeryung
Huh, Kuhl
author_sort Kim, Jee Taek
collection PubMed
description The aim of this study was to investigate the acute effects of ethanol administration on pattern-reversal visual evoked potential (VEP) and multifocal electroretinography (mfERG). Fifteen healthy subjects with no ocular or general disease were recruited. VEP (0.25° pattern sizes) and mfERG with 19 elements in two recording segments were performed before ethanol administration to obtain baseline for each participant. A few days later, the participants visited again for VEP and mfERG measurements after ethanol administration. Ethanol (0.75 g/kg) was administered orally over the course of 30 minutes. VEP and blood alcohol concentration were evaluated one hour after ethanol administration, and mfERG was conducted after pupil dilation. The Wilcoxon signed-rank test was used to compare parameter changes after randomized eye selection. The mean blood alcohol concentration was 0.034% ± 0.05% by volume. VEP revealed a P100 latency delay (109.4 ± 5.3; 113.1 ± 8.2; P = 0.008) after alcohol administration. The P1 implicit time of ring 1 on mfERG showed a trend of shortening after alcohol administration (37.9 ± 1.0; 37.2 ± 1.5; P = 0.048). However, the changes did not show statistical significance after Bonferroni correction. In conclusion, orally administrated ethanol (0.75 g/kg) appears to suppress the central nervous system, but it is not clear whether alcohol intake affects the retina.
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spelling pubmed-48356062016-05-01 The Effects of Alcohol on Visual Evoked Potential and Multifocal Electroretinography Kim, Jee Taek Yun, Cheol Min Kim, Seong-Woo Oh, Jaeryung Huh, Kuhl J Korean Med Sci Original Article The aim of this study was to investigate the acute effects of ethanol administration on pattern-reversal visual evoked potential (VEP) and multifocal electroretinography (mfERG). Fifteen healthy subjects with no ocular or general disease were recruited. VEP (0.25° pattern sizes) and mfERG with 19 elements in two recording segments were performed before ethanol administration to obtain baseline for each participant. A few days later, the participants visited again for VEP and mfERG measurements after ethanol administration. Ethanol (0.75 g/kg) was administered orally over the course of 30 minutes. VEP and blood alcohol concentration were evaluated one hour after ethanol administration, and mfERG was conducted after pupil dilation. The Wilcoxon signed-rank test was used to compare parameter changes after randomized eye selection. The mean blood alcohol concentration was 0.034% ± 0.05% by volume. VEP revealed a P100 latency delay (109.4 ± 5.3; 113.1 ± 8.2; P = 0.008) after alcohol administration. The P1 implicit time of ring 1 on mfERG showed a trend of shortening after alcohol administration (37.9 ± 1.0; 37.2 ± 1.5; P = 0.048). However, the changes did not show statistical significance after Bonferroni correction. In conclusion, orally administrated ethanol (0.75 g/kg) appears to suppress the central nervous system, but it is not clear whether alcohol intake affects the retina. The Korean Academy of Medical Sciences 2016-05 2016-03-15 /pmc/articles/PMC4835606/ /pubmed/27134502 http://dx.doi.org/10.3346/jkms.2016.31.5.783 Text en © 2016 The Korean Academy of Medical Sciences. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Kim, Jee Taek
Yun, Cheol Min
Kim, Seong-Woo
Oh, Jaeryung
Huh, Kuhl
The Effects of Alcohol on Visual Evoked Potential and Multifocal Electroretinography
title The Effects of Alcohol on Visual Evoked Potential and Multifocal Electroretinography
title_full The Effects of Alcohol on Visual Evoked Potential and Multifocal Electroretinography
title_fullStr The Effects of Alcohol on Visual Evoked Potential and Multifocal Electroretinography
title_full_unstemmed The Effects of Alcohol on Visual Evoked Potential and Multifocal Electroretinography
title_short The Effects of Alcohol on Visual Evoked Potential and Multifocal Electroretinography
title_sort effects of alcohol on visual evoked potential and multifocal electroretinography
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835606/
https://www.ncbi.nlm.nih.gov/pubmed/27134502
http://dx.doi.org/10.3346/jkms.2016.31.5.783
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