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Mathematical Model of Three Age-Structured Transmission Dynamics of Chikungunya Virus

We developed a new age-structured deterministic model for the transmission dynamics of chikungunya virus. The model is analyzed to gain insights into the qualitative features of its associated equilibria. Some of the theoretical and epidemiological findings indicate that the stable disease-free equi...

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Autores principales: Agusto, Folashade B., Easley, Shamise, Freeman, Kenneth, Thomas, Madison
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835678/
https://www.ncbi.nlm.nih.gov/pubmed/27190548
http://dx.doi.org/10.1155/2016/4320514
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author Agusto, Folashade B.
Easley, Shamise
Freeman, Kenneth
Thomas, Madison
author_facet Agusto, Folashade B.
Easley, Shamise
Freeman, Kenneth
Thomas, Madison
author_sort Agusto, Folashade B.
collection PubMed
description We developed a new age-structured deterministic model for the transmission dynamics of chikungunya virus. The model is analyzed to gain insights into the qualitative features of its associated equilibria. Some of the theoretical and epidemiological findings indicate that the stable disease-free equilibrium is globally asymptotically stable when the associated reproduction number is less than unity. Furthermore, the model undergoes, in the presence of disease induced mortality, the phenomenon of backward bifurcation, where the stable disease-free equilibrium of the model coexists with a stable endemic equilibrium when the associated reproduction number is less than unity. Further analysis of the model indicates that the qualitative dynamics of the model are not altered by the inclusion of age structure. This is further emphasized by the sensitivity analysis results, which shows that the dominant parameters of the model are not altered by the inclusion of age structure. However, the numerical simulations show the flaw of the exclusion of age in the transmission dynamics of chikungunya with regard to control implementations. The exclusion of age structure fails to show the age distribution needed for an effective age based control strategy, leading to a one size fits all blanket control for the entire population.
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spelling pubmed-48356782016-05-17 Mathematical Model of Three Age-Structured Transmission Dynamics of Chikungunya Virus Agusto, Folashade B. Easley, Shamise Freeman, Kenneth Thomas, Madison Comput Math Methods Med Research Article We developed a new age-structured deterministic model for the transmission dynamics of chikungunya virus. The model is analyzed to gain insights into the qualitative features of its associated equilibria. Some of the theoretical and epidemiological findings indicate that the stable disease-free equilibrium is globally asymptotically stable when the associated reproduction number is less than unity. Furthermore, the model undergoes, in the presence of disease induced mortality, the phenomenon of backward bifurcation, where the stable disease-free equilibrium of the model coexists with a stable endemic equilibrium when the associated reproduction number is less than unity. Further analysis of the model indicates that the qualitative dynamics of the model are not altered by the inclusion of age structure. This is further emphasized by the sensitivity analysis results, which shows that the dominant parameters of the model are not altered by the inclusion of age structure. However, the numerical simulations show the flaw of the exclusion of age in the transmission dynamics of chikungunya with regard to control implementations. The exclusion of age structure fails to show the age distribution needed for an effective age based control strategy, leading to a one size fits all blanket control for the entire population. Hindawi Publishing Corporation 2016 2016-04-05 /pmc/articles/PMC4835678/ /pubmed/27190548 http://dx.doi.org/10.1155/2016/4320514 Text en Copyright © 2016 Folashade B. Agusto et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Agusto, Folashade B.
Easley, Shamise
Freeman, Kenneth
Thomas, Madison
Mathematical Model of Three Age-Structured Transmission Dynamics of Chikungunya Virus
title Mathematical Model of Three Age-Structured Transmission Dynamics of Chikungunya Virus
title_full Mathematical Model of Three Age-Structured Transmission Dynamics of Chikungunya Virus
title_fullStr Mathematical Model of Three Age-Structured Transmission Dynamics of Chikungunya Virus
title_full_unstemmed Mathematical Model of Three Age-Structured Transmission Dynamics of Chikungunya Virus
title_short Mathematical Model of Three Age-Structured Transmission Dynamics of Chikungunya Virus
title_sort mathematical model of three age-structured transmission dynamics of chikungunya virus
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835678/
https://www.ncbi.nlm.nih.gov/pubmed/27190548
http://dx.doi.org/10.1155/2016/4320514
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