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The MHC-II transactivator CIITA inhibits Tat function and HIV-1 replication in human myeloid cells

BACKGROUND: We previously demonstrated that the HLA class II transactivator CIITA inhibits HIV-1 replication in T cells by competing with the viral transactivator Tat for the binding to Cyclin T1 subunit of the P-TEFb complex. Here, we analyzed the anti-viral function of CIITA in myeloid cells, anot...

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Detalles Bibliográficos
Autores principales:	Forlani, Greta, Turrini, Filippo, Ghezzi, Silvia, Tedeschi, Alessandra, Poli, Guido, Accolla, Roberto S., Tosi, Giovanna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835826/ https://www.ncbi.nlm.nih.gov/pubmed/27089879 http://dx.doi.org/10.1186/s12967-016-0853-5

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