Cargando…
Assessment of the retinal nerve fiber layer in individuals with obstructive sleep apnea
BACKGROUND: The effect of obstructive sleep apnea (OSA) syndrome in the peripapillary retinal nerve fiber layer (RNFL) thicknesses remains unclear. The purpose of this study was to assess RNFL measurements acquired using scanning laser polarimetry (SLP) and optical coherence tomography (OCT) in pati...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835866/ https://www.ncbi.nlm.nih.gov/pubmed/27090783 http://dx.doi.org/10.1186/s12886-016-0216-2 |
_version_ | 1782427685989908480 |
---|---|
author | Ferrandez, Blanca Ferreras, Antonio Calvo, Pilar Abadia, Beatriz Marin, Jose M. Pajarin, Ana B. |
author_facet | Ferrandez, Blanca Ferreras, Antonio Calvo, Pilar Abadia, Beatriz Marin, Jose M. Pajarin, Ana B. |
author_sort | Ferrandez, Blanca |
collection | PubMed |
description | BACKGROUND: The effect of obstructive sleep apnea (OSA) syndrome in the peripapillary retinal nerve fiber layer (RNFL) thicknesses remains unclear. The purpose of this study was to assess RNFL measurements acquired using scanning laser polarimetry (SLP) and optical coherence tomography (OCT) in patients with OSA. METHODS: The sample of this cross-sectional study included 40 OSA patients and 45 age-matched controls, consecutively and prospectively selected. All participants underwent at least one reliable standard automated perimetry (SAP) test, while RNFL measurements were obtained using the SLP and OCT. The OSA group was divided into 3 sub-groups based on the apnea/hypopnea index (AHI): mild, moderate, or severe OSA. SAP, SLP, and OCT outcomes were compared between the control and OSA groups. The relationship between AHI and RNFL parameters was also evaluated. RESULTS: Age was not different between both groups. Mean deviation of SAP was −0.47 ± 0.9 dB and −1.43 ± 2.3 dB in the control and OSA groups, respectively (p = 0.01). RNFL thickness measured with OCT was similar between groups. OSA patients showed increased nerve fiber indicator (NFI; 20.9 ± 7.9 versus 16.42 ± 7.82; p = 0.01) and decreased superior average (59.74 ± 10.35 versus 63.73 ± 6.58; p = 0.03) obtained with SLP compared with healthy individuals. In the total sample, NFI and AHI were moderately correlated (r = 0.358; p = 0.001). In severe OSA subjects (n = 22), NFI and AHI had a Spearman correlation coefficient of 0.44 (p = 0.04). CONCLUSION: RNFL thickness measured with OCT did not differ significantly between groups. Severe OSA was related to a reduction of the RNFL thickness assessed by SLP. |
format | Online Article Text |
id | pubmed-4835866 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-48358662016-04-20 Assessment of the retinal nerve fiber layer in individuals with obstructive sleep apnea Ferrandez, Blanca Ferreras, Antonio Calvo, Pilar Abadia, Beatriz Marin, Jose M. Pajarin, Ana B. BMC Ophthalmol Research Article BACKGROUND: The effect of obstructive sleep apnea (OSA) syndrome in the peripapillary retinal nerve fiber layer (RNFL) thicknesses remains unclear. The purpose of this study was to assess RNFL measurements acquired using scanning laser polarimetry (SLP) and optical coherence tomography (OCT) in patients with OSA. METHODS: The sample of this cross-sectional study included 40 OSA patients and 45 age-matched controls, consecutively and prospectively selected. All participants underwent at least one reliable standard automated perimetry (SAP) test, while RNFL measurements were obtained using the SLP and OCT. The OSA group was divided into 3 sub-groups based on the apnea/hypopnea index (AHI): mild, moderate, or severe OSA. SAP, SLP, and OCT outcomes were compared between the control and OSA groups. The relationship between AHI and RNFL parameters was also evaluated. RESULTS: Age was not different between both groups. Mean deviation of SAP was −0.47 ± 0.9 dB and −1.43 ± 2.3 dB in the control and OSA groups, respectively (p = 0.01). RNFL thickness measured with OCT was similar between groups. OSA patients showed increased nerve fiber indicator (NFI; 20.9 ± 7.9 versus 16.42 ± 7.82; p = 0.01) and decreased superior average (59.74 ± 10.35 versus 63.73 ± 6.58; p = 0.03) obtained with SLP compared with healthy individuals. In the total sample, NFI and AHI were moderately correlated (r = 0.358; p = 0.001). In severe OSA subjects (n = 22), NFI and AHI had a Spearman correlation coefficient of 0.44 (p = 0.04). CONCLUSION: RNFL thickness measured with OCT did not differ significantly between groups. Severe OSA was related to a reduction of the RNFL thickness assessed by SLP. BioMed Central 2016-04-18 /pmc/articles/PMC4835866/ /pubmed/27090783 http://dx.doi.org/10.1186/s12886-016-0216-2 Text en © Ferrandez et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Ferrandez, Blanca Ferreras, Antonio Calvo, Pilar Abadia, Beatriz Marin, Jose M. Pajarin, Ana B. Assessment of the retinal nerve fiber layer in individuals with obstructive sleep apnea |
title | Assessment of the retinal nerve fiber layer in individuals with obstructive sleep apnea |
title_full | Assessment of the retinal nerve fiber layer in individuals with obstructive sleep apnea |
title_fullStr | Assessment of the retinal nerve fiber layer in individuals with obstructive sleep apnea |
title_full_unstemmed | Assessment of the retinal nerve fiber layer in individuals with obstructive sleep apnea |
title_short | Assessment of the retinal nerve fiber layer in individuals with obstructive sleep apnea |
title_sort | assessment of the retinal nerve fiber layer in individuals with obstructive sleep apnea |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835866/ https://www.ncbi.nlm.nih.gov/pubmed/27090783 http://dx.doi.org/10.1186/s12886-016-0216-2 |
work_keys_str_mv | AT ferrandezblanca assessmentoftheretinalnervefiberlayerinindividualswithobstructivesleepapnea AT ferrerasantonio assessmentoftheretinalnervefiberlayerinindividualswithobstructivesleepapnea AT calvopilar assessmentoftheretinalnervefiberlayerinindividualswithobstructivesleepapnea AT abadiabeatriz assessmentoftheretinalnervefiberlayerinindividualswithobstructivesleepapnea AT marinjosem assessmentoftheretinalnervefiberlayerinindividualswithobstructivesleepapnea AT pajarinanab assessmentoftheretinalnervefiberlayerinindividualswithobstructivesleepapnea |