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HM71224, a novel Bruton’s tyrosine kinase inhibitor, suppresses B cell and monocyte activation and ameliorates arthritis in a mouse model: a potential drug for rheumatoid arthritis
BACKGROUND: Bruton’s tyrosine kinase (Btk) is critical for activation of B cells and myeloid cells. This study aimed to characterize the effects of HM71224, a novel Btk inhibitor, both in vitro and in a mouse model of experimental arthritis. METHODS: The kinase inhibition profile of HM71224 was anal...
Autores principales: | Park, Jin Kyun, Byun, Joo-Yun, Park, Ji Ah, Kim, Yu-Yon, Lee, Ye Ji, Oh, Jeong In, Jang, Sun Young, Kim, Young Hoon, Song, Yeong Wook, Son, Jeewoong, Suh, Kwee Hyun, Lee, Young-Mi, Lee, Eun Bong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835877/ https://www.ncbi.nlm.nih.gov/pubmed/27090981 http://dx.doi.org/10.1186/s13075-016-0988-z |
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