Cargando…

Modulation of inflammation by autophagy: Consequences for human disease

Autophagy and inflammation are 2 fundamental biological processes involved in both physiological and pathological conditions. Through its crucial role in maintaining cellular homeostasis, autophagy is involved in modulation of cell metabolism, cell survival, and host defense. Defective autophagy is...

Descripción completa

Detalles Bibliográficos
Autores principales: Netea-Maier, Romana T., Plantinga, Theo S., van de Veerdonk, Frank L., Smit, Johannes W., Netea, Mihai G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836004/
https://www.ncbi.nlm.nih.gov/pubmed/26222012
http://dx.doi.org/10.1080/15548627.2015.1071759
_version_ 1782427703342792704
author Netea-Maier, Romana T.
Plantinga, Theo S.
van de Veerdonk, Frank L.
Smit, Johannes W.
Netea, Mihai G.
author_facet Netea-Maier, Romana T.
Plantinga, Theo S.
van de Veerdonk, Frank L.
Smit, Johannes W.
Netea, Mihai G.
author_sort Netea-Maier, Romana T.
collection PubMed
description Autophagy and inflammation are 2 fundamental biological processes involved in both physiological and pathological conditions. Through its crucial role in maintaining cellular homeostasis, autophagy is involved in modulation of cell metabolism, cell survival, and host defense. Defective autophagy is associated with pathological conditions such as cancer, autoimmune disease, neurodegenerative disease, and senescence. Inflammation represents a crucial line of defense against microorganisms and other pathogens, and there is increasing evidence that autophagy has important effects on the induction and modulation of the inflammatory reaction; understanding the balance between these 2 processes may point to important possibilities for therapeutic targeting. This review focuses on the crosstalk between autophagy and inflammation as an emerging field with major implications for understanding the host defense on the one hand, and for the pathogenesis and treatment of immune-mediated diseases on the other hand.
format Online
Article
Text
id pubmed-4836004
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-48360042016-07-29 Modulation of inflammation by autophagy: Consequences for human disease Netea-Maier, Romana T. Plantinga, Theo S. van de Veerdonk, Frank L. Smit, Johannes W. Netea, Mihai G. Autophagy Review Autophagy and inflammation are 2 fundamental biological processes involved in both physiological and pathological conditions. Through its crucial role in maintaining cellular homeostasis, autophagy is involved in modulation of cell metabolism, cell survival, and host defense. Defective autophagy is associated with pathological conditions such as cancer, autoimmune disease, neurodegenerative disease, and senescence. Inflammation represents a crucial line of defense against microorganisms and other pathogens, and there is increasing evidence that autophagy has important effects on the induction and modulation of the inflammatory reaction; understanding the balance between these 2 processes may point to important possibilities for therapeutic targeting. This review focuses on the crosstalk between autophagy and inflammation as an emerging field with major implications for understanding the host defense on the one hand, and for the pathogenesis and treatment of immune-mediated diseases on the other hand. Taylor & Francis 2015-07-29 /pmc/articles/PMC4836004/ /pubmed/26222012 http://dx.doi.org/10.1080/15548627.2015.1071759 Text en © 2016 The Author(s). Published with license by Taylor & Francis. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Review
Netea-Maier, Romana T.
Plantinga, Theo S.
van de Veerdonk, Frank L.
Smit, Johannes W.
Netea, Mihai G.
Modulation of inflammation by autophagy: Consequences for human disease
title Modulation of inflammation by autophagy: Consequences for human disease
title_full Modulation of inflammation by autophagy: Consequences for human disease
title_fullStr Modulation of inflammation by autophagy: Consequences for human disease
title_full_unstemmed Modulation of inflammation by autophagy: Consequences for human disease
title_short Modulation of inflammation by autophagy: Consequences for human disease
title_sort modulation of inflammation by autophagy: consequences for human disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836004/
https://www.ncbi.nlm.nih.gov/pubmed/26222012
http://dx.doi.org/10.1080/15548627.2015.1071759
work_keys_str_mv AT neteamaierromanat modulationofinflammationbyautophagyconsequencesforhumandisease
AT plantingatheos modulationofinflammationbyautophagyconsequencesforhumandisease
AT vandeveerdonkfrankl modulationofinflammationbyautophagyconsequencesforhumandisease
AT smitjohannesw modulationofinflammationbyautophagyconsequencesforhumandisease
AT neteamihaig modulationofinflammationbyautophagyconsequencesforhumandisease