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Modulation of inflammation by autophagy: Consequences for human disease
Autophagy and inflammation are 2 fundamental biological processes involved in both physiological and pathological conditions. Through its crucial role in maintaining cellular homeostasis, autophagy is involved in modulation of cell metabolism, cell survival, and host defense. Defective autophagy is...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836004/ https://www.ncbi.nlm.nih.gov/pubmed/26222012 http://dx.doi.org/10.1080/15548627.2015.1071759 |
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author | Netea-Maier, Romana T. Plantinga, Theo S. van de Veerdonk, Frank L. Smit, Johannes W. Netea, Mihai G. |
author_facet | Netea-Maier, Romana T. Plantinga, Theo S. van de Veerdonk, Frank L. Smit, Johannes W. Netea, Mihai G. |
author_sort | Netea-Maier, Romana T. |
collection | PubMed |
description | Autophagy and inflammation are 2 fundamental biological processes involved in both physiological and pathological conditions. Through its crucial role in maintaining cellular homeostasis, autophagy is involved in modulation of cell metabolism, cell survival, and host defense. Defective autophagy is associated with pathological conditions such as cancer, autoimmune disease, neurodegenerative disease, and senescence. Inflammation represents a crucial line of defense against microorganisms and other pathogens, and there is increasing evidence that autophagy has important effects on the induction and modulation of the inflammatory reaction; understanding the balance between these 2 processes may point to important possibilities for therapeutic targeting. This review focuses on the crosstalk between autophagy and inflammation as an emerging field with major implications for understanding the host defense on the one hand, and for the pathogenesis and treatment of immune-mediated diseases on the other hand. |
format | Online Article Text |
id | pubmed-4836004 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-48360042016-07-29 Modulation of inflammation by autophagy: Consequences for human disease Netea-Maier, Romana T. Plantinga, Theo S. van de Veerdonk, Frank L. Smit, Johannes W. Netea, Mihai G. Autophagy Review Autophagy and inflammation are 2 fundamental biological processes involved in both physiological and pathological conditions. Through its crucial role in maintaining cellular homeostasis, autophagy is involved in modulation of cell metabolism, cell survival, and host defense. Defective autophagy is associated with pathological conditions such as cancer, autoimmune disease, neurodegenerative disease, and senescence. Inflammation represents a crucial line of defense against microorganisms and other pathogens, and there is increasing evidence that autophagy has important effects on the induction and modulation of the inflammatory reaction; understanding the balance between these 2 processes may point to important possibilities for therapeutic targeting. This review focuses on the crosstalk between autophagy and inflammation as an emerging field with major implications for understanding the host defense on the one hand, and for the pathogenesis and treatment of immune-mediated diseases on the other hand. Taylor & Francis 2015-07-29 /pmc/articles/PMC4836004/ /pubmed/26222012 http://dx.doi.org/10.1080/15548627.2015.1071759 Text en © 2016 The Author(s). Published with license by Taylor & Francis. http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
spellingShingle | Review Netea-Maier, Romana T. Plantinga, Theo S. van de Veerdonk, Frank L. Smit, Johannes W. Netea, Mihai G. Modulation of inflammation by autophagy: Consequences for human disease |
title | Modulation of inflammation by autophagy: Consequences for human disease |
title_full | Modulation of inflammation by autophagy: Consequences for human disease |
title_fullStr | Modulation of inflammation by autophagy: Consequences for human disease |
title_full_unstemmed | Modulation of inflammation by autophagy: Consequences for human disease |
title_short | Modulation of inflammation by autophagy: Consequences for human disease |
title_sort | modulation of inflammation by autophagy: consequences for human disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836004/ https://www.ncbi.nlm.nih.gov/pubmed/26222012 http://dx.doi.org/10.1080/15548627.2015.1071759 |
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