The ins and outs of reticulocyte maturation revisited: The role of autophagy in sickle cell disease

Autophagy plays an important role in the removal of membrane bound organelles during the last stage of erythropoiesis as the enucleate reticulocyte matures into the erythrocyte. Autophagic vesicles are expelled from the reticulocyte as intact, inside-out, phosphatidylserine (PS) decorated vesicles a...

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Detalles Bibliográficos
Autores principales: Mankelow, Tosti J., Griffiths, Rebecca E., Trompeter, Sara, Flatt, Joanna F., Cogan, Nicola M., Massey, Edwin J., Anstee, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Autophagic Puncta
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836018/
https://www.ncbi.nlm.nih.gov/pubmed/27046252
http://dx.doi.org/10.1080/15548627.2015.1125072
Descripción
Sumario:Autophagy plays an important role in the removal of membrane bound organelles during the last stage of erythropoiesis as the enucleate reticulocyte matures into the erythrocyte. Autophagic vesicles are expelled from the reticulocyte as intact, inside-out, phosphatidylserine (PS) decorated vesicles and are subsequently removed during splenic passage. Failure to remove these vesicles causes the elevation in PS exposed red cells in Sickle Cell Disease.

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