The ins and outs of reticulocyte maturation revisited: The role of autophagy in sickle cell disease

Autophagy plays an important role in the removal of membrane bound organelles during the last stage of erythropoiesis as the enucleate reticulocyte matures into the erythrocyte. Autophagic vesicles are expelled from the reticulocyte as intact, inside-out, phosphatidylserine (PS) decorated vesicles a...

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Autores principales: Mankelow, Tosti J., Griffiths, Rebecca E., Trompeter, Sara, Flatt, Joanna F., Cogan, Nicola M., Massey, Edwin J., Anstee, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Autophagic Puncta
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836018/
https://www.ncbi.nlm.nih.gov/pubmed/27046252
http://dx.doi.org/10.1080/15548627.2015.1125072
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author Mankelow, Tosti J.
Griffiths, Rebecca E.
Trompeter, Sara
Flatt, Joanna F.
Cogan, Nicola M.
Massey, Edwin J.
Anstee, David J.
author_facet Mankelow, Tosti J.
Griffiths, Rebecca E.
Trompeter, Sara
Flatt, Joanna F.
Cogan, Nicola M.
Massey, Edwin J.
Anstee, David J.
author_sort Mankelow, Tosti J.
collection PubMed
description Autophagy plays an important role in the removal of membrane bound organelles during the last stage of erythropoiesis as the enucleate reticulocyte matures into the erythrocyte. Autophagic vesicles are expelled from the reticulocyte as intact, inside-out, phosphatidylserine (PS) decorated vesicles and are subsequently removed during splenic passage. Failure to remove these vesicles causes the elevation in PS exposed red cells in Sickle Cell Disease.
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spelling pubmed-48360182016-04-29 The ins and outs of reticulocyte maturation revisited: The role of autophagy in sickle cell disease Mankelow, Tosti J. Griffiths, Rebecca E. Trompeter, Sara Flatt, Joanna F. Cogan, Nicola M. Massey, Edwin J. Anstee, David J. Autophagy Autophagic Puncta Autophagy plays an important role in the removal of membrane bound organelles during the last stage of erythropoiesis as the enucleate reticulocyte matures into the erythrocyte. Autophagic vesicles are expelled from the reticulocyte as intact, inside-out, phosphatidylserine (PS) decorated vesicles and are subsequently removed during splenic passage. Failure to remove these vesicles causes the elevation in PS exposed red cells in Sickle Cell Disease. Taylor & Francis 2016-04-05 /pmc/articles/PMC4836018/ /pubmed/27046252 http://dx.doi.org/10.1080/15548627.2015.1125072 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0/, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Autophagic Puncta
Mankelow, Tosti J.
Griffiths, Rebecca E.
Trompeter, Sara
Flatt, Joanna F.
Cogan, Nicola M.
Massey, Edwin J.
Anstee, David J.
The ins and outs of reticulocyte maturation revisited: The role of autophagy in sickle cell disease
title The ins and outs of reticulocyte maturation revisited: The role of autophagy in sickle cell disease
title_full The ins and outs of reticulocyte maturation revisited: The role of autophagy in sickle cell disease
title_fullStr The ins and outs of reticulocyte maturation revisited: The role of autophagy in sickle cell disease
title_full_unstemmed The ins and outs of reticulocyte maturation revisited: The role of autophagy in sickle cell disease
title_short The ins and outs of reticulocyte maturation revisited: The role of autophagy in sickle cell disease
title_sort ins and outs of reticulocyte maturation revisited: the role of autophagy in sickle cell disease
topic Autophagic Puncta
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836018/
https://www.ncbi.nlm.nih.gov/pubmed/27046252
http://dx.doi.org/10.1080/15548627.2015.1125072
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