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C-reactive protein as a prognostic factor in patients with chordoma of lumbar spine and sacrum—a single center pilot study

STUDY DESIGN: This is a retrospective, diagnostic study, level IV. BACKGROUND: It appears to be necessary to identify prognostic markers for individual risk estimation for progression and survival in patients with chordoma, a rare disease. Are pre-operative serum levels of C-reactive protein (CRP) a...

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Autores principales: Hobusch, Gerhard Martin, Bodner, Florian, Walzer, Sonja, Marculescu, Rodrig, Funovics, Philipp T., Sulzbacher, Irene, Windhager, Reinhard, Panotopoulos, Joannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836072/
https://www.ncbi.nlm.nih.gov/pubmed/27091202
http://dx.doi.org/10.1186/s12957-016-0875-8
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author Hobusch, Gerhard Martin
Bodner, Florian
Walzer, Sonja
Marculescu, Rodrig
Funovics, Philipp T.
Sulzbacher, Irene
Windhager, Reinhard
Panotopoulos, Joannis
author_facet Hobusch, Gerhard Martin
Bodner, Florian
Walzer, Sonja
Marculescu, Rodrig
Funovics, Philipp T.
Sulzbacher, Irene
Windhager, Reinhard
Panotopoulos, Joannis
author_sort Hobusch, Gerhard Martin
collection PubMed
description STUDY DESIGN: This is a retrospective, diagnostic study, level IV. BACKGROUND: It appears to be necessary to identify prognostic markers for individual risk estimation for progression and survival in patients with chordoma, a rare disease. Are pre-operative serum levels of C-reactive protein (CRP) associated with disease progression and survival? METHODS: Survival rates of 24 patients (18 males, 6 females) (mean age 67 years (SD ± 16; range 20–85 years); minimum follow-up 2 years, mean follow-up 5 years (SD ± 5; range 2–19 years)) with chordoma of the lower spine and sacrum were assessed with a focus on pre-operative CRP levels. RESULTS: The survival rate of patients with pre-operative CRP level of >1.0 mg/dl was lower than that of patients with a CRP level <1.0 mg/dl (p = 0.01). The estimated 10-year survival of patients with pre-operative CRP values <1.0 and >1.0 mg/dl was 76 and 25 %, respectively. CRP remained as an independent survival factor (p = 0.025; CI 95 % 1.0–2.6) in multivariable analysis. CONCLUSIONS: Pre-operative CRP levels appear to be a biomarker for disease-specific survival in patients with chordoma of the lumbar spine and sacrum. A validation of our finding with larger cohorts and integration of putative risk factor would further elucidate CRP a surrogate for tumor progression.
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spelling pubmed-48360722016-04-20 C-reactive protein as a prognostic factor in patients with chordoma of lumbar spine and sacrum—a single center pilot study Hobusch, Gerhard Martin Bodner, Florian Walzer, Sonja Marculescu, Rodrig Funovics, Philipp T. Sulzbacher, Irene Windhager, Reinhard Panotopoulos, Joannis World J Surg Oncol Research STUDY DESIGN: This is a retrospective, diagnostic study, level IV. BACKGROUND: It appears to be necessary to identify prognostic markers for individual risk estimation for progression and survival in patients with chordoma, a rare disease. Are pre-operative serum levels of C-reactive protein (CRP) associated with disease progression and survival? METHODS: Survival rates of 24 patients (18 males, 6 females) (mean age 67 years (SD ± 16; range 20–85 years); minimum follow-up 2 years, mean follow-up 5 years (SD ± 5; range 2–19 years)) with chordoma of the lower spine and sacrum were assessed with a focus on pre-operative CRP levels. RESULTS: The survival rate of patients with pre-operative CRP level of >1.0 mg/dl was lower than that of patients with a CRP level <1.0 mg/dl (p = 0.01). The estimated 10-year survival of patients with pre-operative CRP values <1.0 and >1.0 mg/dl was 76 and 25 %, respectively. CRP remained as an independent survival factor (p = 0.025; CI 95 % 1.0–2.6) in multivariable analysis. CONCLUSIONS: Pre-operative CRP levels appear to be a biomarker for disease-specific survival in patients with chordoma of the lumbar spine and sacrum. A validation of our finding with larger cohorts and integration of putative risk factor would further elucidate CRP a surrogate for tumor progression. BioMed Central 2016-04-18 /pmc/articles/PMC4836072/ /pubmed/27091202 http://dx.doi.org/10.1186/s12957-016-0875-8 Text en © Hobusch et al. 2016 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Hobusch, Gerhard Martin
Bodner, Florian
Walzer, Sonja
Marculescu, Rodrig
Funovics, Philipp T.
Sulzbacher, Irene
Windhager, Reinhard
Panotopoulos, Joannis
C-reactive protein as a prognostic factor in patients with chordoma of lumbar spine and sacrum—a single center pilot study
title C-reactive protein as a prognostic factor in patients with chordoma of lumbar spine and sacrum—a single center pilot study
title_full C-reactive protein as a prognostic factor in patients with chordoma of lumbar spine and sacrum—a single center pilot study
title_fullStr C-reactive protein as a prognostic factor in patients with chordoma of lumbar spine and sacrum—a single center pilot study
title_full_unstemmed C-reactive protein as a prognostic factor in patients with chordoma of lumbar spine and sacrum—a single center pilot study
title_short C-reactive protein as a prognostic factor in patients with chordoma of lumbar spine and sacrum—a single center pilot study
title_sort c-reactive protein as a prognostic factor in patients with chordoma of lumbar spine and sacrum—a single center pilot study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836072/
https://www.ncbi.nlm.nih.gov/pubmed/27091202
http://dx.doi.org/10.1186/s12957-016-0875-8
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