Glutamate carboxypeptidase II gene knockout attenuates oxidative stress and cortical apoptosis after traumatic brain injury

BACKGROUND: Glutamate carboxypeptidase II (GCPII) inactivates the peptide co-transmitter N-acetylaspartylglutamate following synaptic release. Inhibition of GCPII elevates extracellular levels of the peptide, inhibits glutamate release and is neuroprotective in an animal model of traumatic brain inj...

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Detalles Bibliográficos
Autores principales: Cao, Yang, Gao, Yang, Xu, Siyi, Bao, Jingang, Lin, Yingying, Luo, Xingguang, Wang, Yong, Luo, Qizhong, Jiang, Jiyao, Neale, Joseph H., Zhong, Chunlong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836105/
https://www.ncbi.nlm.nih.gov/pubmed/27091009
http://dx.doi.org/10.1186/s12868-016-0251-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836105/
https://www.ncbi.nlm.nih.gov/pubmed/27091009
http://dx.doi.org/10.1186/s12868-016-0251-1

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