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Infections During Induction Therapy of Protocol CCLG-2008 in Childhood Acute Lymphoblastic Leukemia: A Single-center Experience with 256 Cases in China
BACKGROUND: Infections remain a major cause of therapy-associated morbidity and mortality in children with acute lymphoblastic leukemia (ALL). METHODS: We retrospectively analyzed the medical charts of 256 children treated for ALL under the CCLG-2008 protocol in Beijing Children's Hospital. RES...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836249/ https://www.ncbi.nlm.nih.gov/pubmed/25673448 http://dx.doi.org/10.4103/0366-6999.151085 |
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author | Li, Si-Dan Chen, Yong-Bing Li, Zhi-Gang Wu, Run-Hui Qin, Mao-Quan Zhou, Xuan Jiang, Jin Zhang, Rui-Dong Xie, Jing Ma, Xiao-Li Zhang, Rui Wang, Bin Wu, Ying Zheng, Hu-Yong Wu, Min-Yuan |
author_facet | Li, Si-Dan Chen, Yong-Bing Li, Zhi-Gang Wu, Run-Hui Qin, Mao-Quan Zhou, Xuan Jiang, Jin Zhang, Rui-Dong Xie, Jing Ma, Xiao-Li Zhang, Rui Wang, Bin Wu, Ying Zheng, Hu-Yong Wu, Min-Yuan |
author_sort | Li, Si-Dan |
collection | PubMed |
description | BACKGROUND: Infections remain a major cause of therapy-associated morbidity and mortality in children with acute lymphoblastic leukemia (ALL). METHODS: We retrospectively analyzed the medical charts of 256 children treated for ALL under the CCLG-2008 protocol in Beijing Children's Hospital. RESULTS: There were 65 infectious complications in 50 patients during vincristine, daunorubicin, L-asparaginase and dexamethasone induction therapy, including microbiologically documented infections (n = 12; 18.5%), clinically documented infections (n = 23; 35.3%) and fever of unknown origin (n = 30; 46.2%). Neutropenia was present in 83.1% of the infectious episodes. In all, most infections occurred around the 15(th) day of induction treatment (n = 28), and no patients died of infection-associated complications. CONCLUSIONS: The infections in this study was independent of treatment response, minimal residual diseases at the end of induction therapy, gender, immunophenotype, infection at first visit, risk stratification at diagnosis, unfavorable karyotypes at diagnosis and morphologic type. The infection rate of CCLG-2008 induction therapy is low, and the outcome of patients is favorable. |
format | Online Article Text |
id | pubmed-4836249 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-48362492016-04-29 Infections During Induction Therapy of Protocol CCLG-2008 in Childhood Acute Lymphoblastic Leukemia: A Single-center Experience with 256 Cases in China Li, Si-Dan Chen, Yong-Bing Li, Zhi-Gang Wu, Run-Hui Qin, Mao-Quan Zhou, Xuan Jiang, Jin Zhang, Rui-Dong Xie, Jing Ma, Xiao-Li Zhang, Rui Wang, Bin Wu, Ying Zheng, Hu-Yong Wu, Min-Yuan Chin Med J (Engl) Original Article BACKGROUND: Infections remain a major cause of therapy-associated morbidity and mortality in children with acute lymphoblastic leukemia (ALL). METHODS: We retrospectively analyzed the medical charts of 256 children treated for ALL under the CCLG-2008 protocol in Beijing Children's Hospital. RESULTS: There were 65 infectious complications in 50 patients during vincristine, daunorubicin, L-asparaginase and dexamethasone induction therapy, including microbiologically documented infections (n = 12; 18.5%), clinically documented infections (n = 23; 35.3%) and fever of unknown origin (n = 30; 46.2%). Neutropenia was present in 83.1% of the infectious episodes. In all, most infections occurred around the 15(th) day of induction treatment (n = 28), and no patients died of infection-associated complications. CONCLUSIONS: The infections in this study was independent of treatment response, minimal residual diseases at the end of induction therapy, gender, immunophenotype, infection at first visit, risk stratification at diagnosis, unfavorable karyotypes at diagnosis and morphologic type. The infection rate of CCLG-2008 induction therapy is low, and the outcome of patients is favorable. Medknow Publications & Media Pvt Ltd 2015-02-20 /pmc/articles/PMC4836249/ /pubmed/25673448 http://dx.doi.org/10.4103/0366-6999.151085 Text en Copyright: © 2015 Chinese Medical Journal http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Li, Si-Dan Chen, Yong-Bing Li, Zhi-Gang Wu, Run-Hui Qin, Mao-Quan Zhou, Xuan Jiang, Jin Zhang, Rui-Dong Xie, Jing Ma, Xiao-Li Zhang, Rui Wang, Bin Wu, Ying Zheng, Hu-Yong Wu, Min-Yuan Infections During Induction Therapy of Protocol CCLG-2008 in Childhood Acute Lymphoblastic Leukemia: A Single-center Experience with 256 Cases in China |
title | Infections During Induction Therapy of Protocol CCLG-2008 in Childhood Acute Lymphoblastic Leukemia: A Single-center Experience with 256 Cases in China |
title_full | Infections During Induction Therapy of Protocol CCLG-2008 in Childhood Acute Lymphoblastic Leukemia: A Single-center Experience with 256 Cases in China |
title_fullStr | Infections During Induction Therapy of Protocol CCLG-2008 in Childhood Acute Lymphoblastic Leukemia: A Single-center Experience with 256 Cases in China |
title_full_unstemmed | Infections During Induction Therapy of Protocol CCLG-2008 in Childhood Acute Lymphoblastic Leukemia: A Single-center Experience with 256 Cases in China |
title_short | Infections During Induction Therapy of Protocol CCLG-2008 in Childhood Acute Lymphoblastic Leukemia: A Single-center Experience with 256 Cases in China |
title_sort | infections during induction therapy of protocol cclg-2008 in childhood acute lymphoblastic leukemia: a single-center experience with 256 cases in china |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836249/ https://www.ncbi.nlm.nih.gov/pubmed/25673448 http://dx.doi.org/10.4103/0366-6999.151085 |
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