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The Proteolytic Activation of (H3N2) Influenza A Virus Hemagglutinin Is Facilitated by Different Type II Transmembrane Serine Proteases

Cleavage of influenza virus hemagglutinin (HA) by host cell proteases is necessary for viral activation and infectivity. In humans and mice, members of the type II transmembrane protease family (TTSP), e.g., TMPRSS2, TMPRSS4, and TMPRSS11d (HAT), have been shown to cleave influenza virus HA for vira...

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Detalles Bibliográficos
Autores principales:	Kühn, Nora, Bergmann, Silke, Kösterke, Nadine, Lambertz, Ruth L. O., Keppner, Anna, van den Brand, Judith M. A., Pöhlmann, Stefan, Weiß, Siegfried, Hummler, Edith, Hatesuer, Bastian, Schughart, Klaus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2016
Materias:	Pathogenesis and Immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836353/ https://www.ncbi.nlm.nih.gov/pubmed/26889029 http://dx.doi.org/10.1128/JVI.02693-15

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