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Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicing
Pre-mRNA splicing must occur with high fidelity and efficiency for proper gene expression. The spliceosome uses DExD/H box helicases to promote on-pathway interactions while simultaneously minimizing errors. Prp8 and Snu114, an EF2-like GTPase, regulate the activity of the Brr2 helicase, promoting R...
Autores principales: | Mayerle, Megan, Guthrie, Christine |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836653/ https://www.ncbi.nlm.nih.gov/pubmed/26968627 http://dx.doi.org/10.1261/rna.055459.115 |
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