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Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere

[Image: see text] Bioisosteric replacements are widely used in medicinal chemistry to improve physicochemical and ADME properties of molecules while retaining or improving affinity. Here, using the p53 cancer mutant Y220C as a test case, we investigate both computationally and experimentally whether...

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Detalles Bibliográficos
Autores principales:	Wilcken, Rainer, Zimmermann, Markus O., Bauer, Matthias R., Rutherford, Trevor J., Fersht, Alan R., Joerger, Andreas C., Boeckler, Frank M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2015
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836799/ https://www.ncbi.nlm.nih.gov/pubmed/26378745 http://dx.doi.org/10.1021/acschembio.5b00515

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