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DNA polymerase-α regulates type I interferon activation through cytosolic RNA:DNA synthesis
Aberrant nucleic acids generated during viral replication are the main trigger for antiviral immunity, and mutations disrupting nucleic acid metabolism can lead to autoinflammatory disorders. Here we investigated the etiology of X-linked reticulate pigmentary disorder (XLPDR), a primary immunodefici...
Autores principales: | Starokadomskyy, Petro, Gemelli, Terry, Rios, Jonathan J., Xing, Chao, Wang, Richard C., Li, Haiying, Pokatayev, Vladislav, Dozmorov, Igor, Khan, Shaheen, Miyata, Naoteru, Fraile, Guadalupe, Raj, Prithvi, Xu, Zhe, Xu, Zigang, Ma, Lin, Lin, Zhimiao, Wang, Huijun, Yang, Yong, Ben-Amitai, Dan, Orenstein, Naama, Mussaffi, Huda, Baselga, Eulalia, Tadini, Gianluca, Grunebaum, Eyal, Sarajlija, Adrijan, Krzewski, Konrad, Wakeland, Edward K., Yan, Nan, de la Morena, Maria Teresa, Zinn, Andrew R., Burstein, Ezra |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836962/ https://www.ncbi.nlm.nih.gov/pubmed/27019227 http://dx.doi.org/10.1038/ni.3409 |
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