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Essential biphasic role for JAK3 catalytic activity in IL-2 receptor signaling
To drive lymphocyte proliferation and differentiation, common γ-chain (γ(c)) cytokine receptors require hours to days of sustained stimulation. While JAK1 and JAK3 kinases are found together in all γ(c)-receptor complexes, it is not known how their respective catalytic activities contribute to signa...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837022/ https://www.ncbi.nlm.nih.gov/pubmed/27018889 http://dx.doi.org/10.1038/nchembio.2056 |