Protein phosphatase 2A is requisite for the function of regulatory T cells

Immune homeostasis depends on the proper function of regulatory T (T(reg)) cells. Compromised T(reg) cell suppressive activity leads to autoimmune disease, graft rejection and promotes anti-tumor immunity. Here we report the previously unrecognized requirement of the serine/threonine phosphatase Pro...

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Detalles Bibliográficos
Autores principales: Apostolidis, Sokratis A., Rodríguez-Rodríguez, Noé, Suárez-Fueyo, Abel, Dioufa, Nikolina, Ozcan, Esra, Crispín, José C., Tsokos, Maria G., Tsokos, George C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837024/
https://www.ncbi.nlm.nih.gov/pubmed/26974206
http://dx.doi.org/10.1038/ni.3390
Descripción
Sumario:Immune homeostasis depends on the proper function of regulatory T (T(reg)) cells. Compromised T(reg) cell suppressive activity leads to autoimmune disease, graft rejection and promotes anti-tumor immunity. Here we report the previously unrecognized requirement of the serine/threonine phosphatase Protein Phosphatase 2A (PP2A) for the function of T(reg) cells. T(reg) cells exhibited high PP2A activity and T(reg) cell-specific ablation of the PP2A complex resulted in a severe, multi-organ, lymphoproliferative autoimmune disorder. Mass spectrometric analysis revealed that PP2A associates with components of the mTOR pathway and suppresses mTORC1 activity. In the absence of PP2A, T(reg) cells altered their metabolic and cytokine profile and were unable to suppress effector immune responses. Therefore, PP2A is requisite for the function of T(reg) cells and the prevention of autoimmunity.

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