Antagonism of Stem Cell Factor/c-kit Signaling Attenuates Neonatal Chronic Hypoxia-Induced Pulmonary Vascular Remodeling

BACKGROUND: Accumulating evidence suggests that c-kit positive cells are present in the remodeled pulmonary vasculature bed of patients with pulmonary hypertension (PH). Whether stem cell factor (SCF)/ c-kit regulated pathways potentiate pulmonary vascular remodeling is unknown. Here, we tested the...

Descripción completa

Detalles Bibliográficos
Autores principales: Young, Karen C, Torres, Eneida, Hehre, Dorothy, Wu, Shu, Suguihara, Cleide, Hare, Joshua M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837030/
https://www.ncbi.nlm.nih.gov/pubmed/26705118
http://dx.doi.org/10.1038/pr.2015.275

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837030/
https://www.ncbi.nlm.nih.gov/pubmed/26705118
http://dx.doi.org/10.1038/pr.2015.275

Ejemplares similares