Tirofiban-Induced Thrombocytopenia Occurring with Crohn's Disease

A 69-year-old man, with severe refractory Crohn's disease, presented with acute coronary syndrome that required angioplasty. He developed severe tirofiban-induced thrombocytopenia (TIT) heralded by type I allergic reaction that required steroids and a combination of antihistamine H1 and antihis...

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Detalles Bibliográficos
Autores principales: Ibrahim, Toni, El Karak, Fady, Araji, Assem, El Rassy, Elie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837249/
https://www.ncbi.nlm.nih.gov/pubmed/27144035
http://dx.doi.org/10.1155/2016/4605139
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author Ibrahim, Toni
El Karak, Fady
Araji, Assem
El Rassy, Elie
author_facet Ibrahim, Toni
El Karak, Fady
Araji, Assem
El Rassy, Elie
author_sort Ibrahim, Toni
collection PubMed
description A 69-year-old man, with severe refractory Crohn's disease, presented with acute coronary syndrome that required angioplasty. He developed severe tirofiban-induced thrombocytopenia (TIT) heralded by type I allergic reaction that required steroids and a combination of antihistamine H1 and antihistamine H2 for symptomatic management. The thrombocytopenia spontaneously resolved uneventfully in 48 hours thereafter. This case report suggests a possible association between TIT and inflammatory bowel disease. Therefore, strict monitoring of the platelet count is required in patients who develop allergic reactions to tirofiban.
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spelling pubmed-48372492016-05-03 Tirofiban-Induced Thrombocytopenia Occurring with Crohn's Disease Ibrahim, Toni El Karak, Fady Araji, Assem El Rassy, Elie Case Rep Cardiol Case Report A 69-year-old man, with severe refractory Crohn's disease, presented with acute coronary syndrome that required angioplasty. He developed severe tirofiban-induced thrombocytopenia (TIT) heralded by type I allergic reaction that required steroids and a combination of antihistamine H1 and antihistamine H2 for symptomatic management. The thrombocytopenia spontaneously resolved uneventfully in 48 hours thereafter. This case report suggests a possible association between TIT and inflammatory bowel disease. Therefore, strict monitoring of the platelet count is required in patients who develop allergic reactions to tirofiban. Hindawi Publishing Corporation 2016 2016-04-06 /pmc/articles/PMC4837249/ /pubmed/27144035 http://dx.doi.org/10.1155/2016/4605139 Text en Copyright © 2016 Toni Ibrahim et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Ibrahim, Toni
El Karak, Fady
Araji, Assem
El Rassy, Elie
Tirofiban-Induced Thrombocytopenia Occurring with Crohn's Disease
title Tirofiban-Induced Thrombocytopenia Occurring with Crohn's Disease
title_full Tirofiban-Induced Thrombocytopenia Occurring with Crohn's Disease
title_fullStr Tirofiban-Induced Thrombocytopenia Occurring with Crohn's Disease
title_full_unstemmed Tirofiban-Induced Thrombocytopenia Occurring with Crohn's Disease
title_short Tirofiban-Induced Thrombocytopenia Occurring with Crohn's Disease
title_sort tirofiban-induced thrombocytopenia occurring with crohn's disease
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837249/
https://www.ncbi.nlm.nih.gov/pubmed/27144035
http://dx.doi.org/10.1155/2016/4605139
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