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A healthy gastrointestinal microbiome is dependent on dietary diversity
BACKGROUND: Like all healthy ecosystems, richness of microbiota species characterizes the GI microbiome in healthy individuals. Conversely, a loss in species diversity is a common finding in several disease states. This biome is flooded with energy in the form of undigested and partially digested fo...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837298/ https://www.ncbi.nlm.nih.gov/pubmed/27110483 http://dx.doi.org/10.1016/j.molmet.2016.02.005 |
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author | Heiman, Mark L. Greenway, Frank L. |
author_facet | Heiman, Mark L. Greenway, Frank L. |
author_sort | Heiman, Mark L. |
collection | PubMed |
description | BACKGROUND: Like all healthy ecosystems, richness of microbiota species characterizes the GI microbiome in healthy individuals. Conversely, a loss in species diversity is a common finding in several disease states. This biome is flooded with energy in the form of undigested and partially digested foods, and in some cases drugs and dietary supplements. Each microbiotic species in the biome transforms that energy into new molecules, which may signal messages to physiological systems of the host. SCOPE OF REVIEW: Dietary choices select substrates for species, providing a competitive advantage over other GI microbiota. The more diverse the diet, the more diverse the microbiome and the more adaptable it will be to perturbations. Unfortunately, dietary diversity has been lost during the past 50 years and dietary choices that exclude food products from animals or plants will narrow the GI microbiome further. MAJOR CONCLUSION: Additional research into expanding gut microbial richness by dietary diversity is likely to expand concepts in healthy nutrition, stimulate discovery of new diagnostics, and open up novel therapeutic possibilities. |
format | Online Article Text |
id | pubmed-4837298 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-48372982016-04-22 A healthy gastrointestinal microbiome is dependent on dietary diversity Heiman, Mark L. Greenway, Frank L. Mol Metab Review BACKGROUND: Like all healthy ecosystems, richness of microbiota species characterizes the GI microbiome in healthy individuals. Conversely, a loss in species diversity is a common finding in several disease states. This biome is flooded with energy in the form of undigested and partially digested foods, and in some cases drugs and dietary supplements. Each microbiotic species in the biome transforms that energy into new molecules, which may signal messages to physiological systems of the host. SCOPE OF REVIEW: Dietary choices select substrates for species, providing a competitive advantage over other GI microbiota. The more diverse the diet, the more diverse the microbiome and the more adaptable it will be to perturbations. Unfortunately, dietary diversity has been lost during the past 50 years and dietary choices that exclude food products from animals or plants will narrow the GI microbiome further. MAJOR CONCLUSION: Additional research into expanding gut microbial richness by dietary diversity is likely to expand concepts in healthy nutrition, stimulate discovery of new diagnostics, and open up novel therapeutic possibilities. Elsevier 2016-03-05 /pmc/articles/PMC4837298/ /pubmed/27110483 http://dx.doi.org/10.1016/j.molmet.2016.02.005 Text en © 2016 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Heiman, Mark L. Greenway, Frank L. A healthy gastrointestinal microbiome is dependent on dietary diversity |
title | A healthy gastrointestinal microbiome is dependent on dietary diversity |
title_full | A healthy gastrointestinal microbiome is dependent on dietary diversity |
title_fullStr | A healthy gastrointestinal microbiome is dependent on dietary diversity |
title_full_unstemmed | A healthy gastrointestinal microbiome is dependent on dietary diversity |
title_short | A healthy gastrointestinal microbiome is dependent on dietary diversity |
title_sort | healthy gastrointestinal microbiome is dependent on dietary diversity |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837298/ https://www.ncbi.nlm.nih.gov/pubmed/27110483 http://dx.doi.org/10.1016/j.molmet.2016.02.005 |
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