Inter-domain tagging implicates caveolin-1 in insulin receptor trafficking and Erk signaling bias in pancreatic beta-cells

OBJECTIVE: The role and mechanisms of insulin receptor internalization remain incompletely understood. Previous trafficking studies of insulin receptors involved fluorescent protein tagging at their termini, manipulations that may be expected to result in dysfunctional receptors. Our objective was t...

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Detalles Bibliográficos
Autores principales: Boothe, Tobias, Lim, Gareth E., Cen, Haoning, Skovsø, Søs, Piske, Micah, Li, Shu Nan, Nabi, Ivan R., Gilon, Patrick, Johnson, James D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4837300/
https://www.ncbi.nlm.nih.gov/pubmed/27110488
http://dx.doi.org/10.1016/j.molmet.2016.01.009

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